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Review

Noteworthy Comment: This paper discusses an issue of growing importance that is the focus of attention in gerontology and anti-aging therapies. Loss of muscle or sarcopenia and frailty progressively erode quality of life, independent living and eventually increase the risk for development of intrinsic diseases of aging. The authors have reviewed recent literatures of frailty syndrome and summarized its clinical applications and potential preventative and therapeutic interventions. My overall expression is that the paper is well written and has the potential to attract significant attention from health care practitioners focused upon aging and its consequences.

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Frailty syndrome: an overview

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