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Evaluation of therapeutic effect of tumor-targeted therapy
Authors Li, Li, Shen, Fang, Huang, Yuan Y
Received 24 July 2012
Accepted for publication 21 August 2012
Published 17 September 2012 Volume 2012:5 Pages 191—198
DOI https://doi.org/10.2147/OTT.S36307
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Xiao-fen Li,1 Mo-dan Li,1 Hong Shen,1 Xue-feng Fang,1 Pin-tong Huang,2 Ying Yuan1
1Department of Medical Oncology, 2Department of Ultrasonography, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Abstract: The response evaluation criteria in solid tumors, which are based on tumor size alone, are the most frequently used and effective criteria by which to evaluate the tumor response to chemotherapy. However, the mechanism of tumor-targeted drugs is different from traditional cytotoxic drugs. Tumor-targeted drugs are designed to interfere with specific aberrant biological pathways involved in tumorigenesis. For this reason, the response evaluation in solid tumors is not adequate for the evaluation of targeted therapy. Molecular and functional imaging techniques such as dynamic contrast-enhanced perfusion computed tomography, dynamic contrast-enhanced magnetic resonance imaging, dynamic contrast-enhanced ultrasound, and fluorodeoxyglucose-positron emission tomography can reflect tumor blood flow and cellular metabolic changes directly, and are being used more frequently for the evaluation of targeted therapies. This article gives an overview of some of the new computed tomography criteria and the commonly used methods of targeted therapy evaluation.
Keywords: evaluation of therapeutic effect, targeted therapy, tumor
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