Drug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19New articles released by Dove Press for Drug Design, Development and Therapyen-us2026, Dove Pressangela@dovepress.com (Angela Jones)Dove Press Drug Design, Development and TherapyDrug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19https://www.dovepress.com/assets/img/addon/rss-banner.jpg140140Recent Advances in the Study of Traditional Chinese Medicine in Reversing Hepatic Fibrosis Through the Regulation of Hepatic Stellate Cells Apoptosis Pathwayshttps://www.dovepress.com/recent-advances-in-the-study-of-traditional-chinese-medicine-in-revers-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 15 Jun 2026 17:35:00 +1200https://doi.org/10.2147/DDDT.S602887A Comparison of Tegileridine Fumarate versus Sufentanil on the Quality of Postoperative Recovery After Laparoscopic Sleeve Gastrectomy: A Preliminary Randomized Controlled Trialhttps://www.dovepress.com/a-comparison-of-tegileridine-fumarate-versus-sufentanil-on-the-quality-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 15 Jun 2026 17:30:00 +1200https://doi.org/10.2147/DDDT.S611241Anlotinib as Third-Line or Later Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Real-World Efficacy and Safety Outcomeshttps://www.dovepress.com/anlotinib-as-third-line-or-later-therapy-in-recurrent-or-metastatic-he-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 12 Jun 2026 19:55:00 +1200https://doi.org/10.2147/DDDT.S584230Protective Effect of Salidroside Against Multiple Organs Ischemia-Reperfusion Injury: New Insights From Common and Specific Pharmacological Mechanismshttps://www.dovepress.com/protective-effect-of-salidroside-against-multiple-organs-ischemia-repe-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 12 Jun 2026 18:55:00 +1200https://doi.org/10.2147/DDDT.S608894GLP-1 Receptor Agonists in Neurological Disorders: From Mechanisms to Clinical Translationhttps://www.dovepress.com/glp-1-receptor-agonists-in-neurological-disorders-from-mechanisms-to-c-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 12 Jun 2026 01:20:00 +1200https://doi.org/10.2147/DDDT.S613616Determination of the ED50 of Tegileridine and Comparison with Fentanyl for Analgesia During Hysteroscopy in Chinese Female Patients: An Exploratory Sequential Dose‑Finding Studyhttps://www.dovepress.com/determination-of-the-ed50-of-tegileridine-and-comparison-with-fentanyl-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 12 Jun 2026 01:15:00 +1200https://doi.org/10.2147/DDDT.S608163Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial [Letter]https://www.dovepress.com/effects-of-remimazolam-dose-and-bolus-injection-rate-on-hiccups-duri-2-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 11 Jun 2026 18:05:00 +1200https://doi.org/10.2147/DDDT.S627915Toward Optimized Platinum Therapy: A Risk Prediction Model for Toxicity Based on Platinum Accumulation and Its Impact on Treatment Outcomeshttps://www.dovepress.com/toward-optimized-platinum-therapy-a-risk-prediction-model-for-toxicity-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 10 Jun 2026 19:55:00 +1200https://doi.org/10.2147/DDDT.S600037Effect of End-Stage Kidney Disease Factor on the Sedative Effects of Ciprofolhttps://www.dovepress.com/effect-of-end-stage-kidney-disease-factor-on-the-sedative-effects-of-c-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 10 Jun 2026 03:25:00 +1200https://doi.org/10.2147/DDDT.S601965Isobolographic Analysis of the Interaction Between Remimazolam and Etomidate in General Anesthesia Induction: A Prospective, Sequential Allocation Study Based on the Dixon Up-and-Down Methodhttps://www.dovepress.com/isobolographic-analysis-of-the-interaction-between-remimazolam-and-eto-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 10 Jun 2026 03:20:00 +1200https://doi.org/10.2147/DDDT.S597710Identification of Antibacterial Hits Associated with Penicillin-Binding Protein 2 in Escherichia coli Using a Comprehensive Property Spectrum and Fivefold Maximum Drug-Likeness Strategyhttps://www.dovepress.com/identification-of-antibacterial-hits-associated-with-penicillin-bindin-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 09 Jun 2026 19:00:00 +1200https://doi.org/10.2147/DDDT.S595430Determination of the ED90 for Epidural Hydromorphone and Morphine for Postoperative Pain Using a Biased-Coin Up-and-Down Sequential Design After Elective Cesarean Deliveryhttps://www.dovepress.com/determination-of-the-ed90-for-epidural-hydromorphone-and-morphine-for--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 09 Jun 2026 17:40:00 +1200https://doi.org/10.2147/DDDT.S588767Paeoniflorin as a Promising Therapeutic Candidate in Intestinal Diseases: Experimental Evidence, Mechanistic Insights, and Translational Perspectiveshttps://www.dovepress.com/paeoniflorin-as-a-promising-therapeutic-candidate-in-intestinal-diseas-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 09 Jun 2026 16:50:00 +1200https://doi.org/10.2147/DDDT.S617375Age-Stratified ED95 of Remimazolam Tosilate for Moderate Sedation in Pediatric Patients: A Biased Coin Design Studyhttps://www.dovepress.com/age-stratified-ed95-of-remimazolam-tosilate-for-moderate-sedation-in-p-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 23:40:00 +1200https://doi.org/10.2147/DDDT.S613464Oliceridine in the Prevention of Catheter-Related Bladder Discomfort: A Single-Center, Randomized, Double-Blind, Prospective Trialhttps://www.dovepress.com/oliceridine-in-the-prevention-of-catheter-related-bladder-discomfort-a-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 22:20:00 +1200https://doi.org/10.2147/DDDT.S605184A Dual-Function Gastroretentive System: Enhancing Ofloxacin Bioavailability via Floating-Bioadhesive Pellets Based on a Hollow Structure Prepared with a Hybrid Polymer Filmhttps://www.dovepress.com/a-dual-function-gastroretentive-system-enhancing-ofloxacin-bioavailabi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 22:15:00 +1200https://doi.org/10.2147/DDDT.S589908Mivacurium Infusion ED50/ED95 for Maintaining Motor Evoked Potentials During Adolescent Scoliosis Surgery Under TIVA: A Modified Dixon Up-and-Down Sequential Dose-Finding Studyhttps://www.dovepress.com/mivacurium-infusion-ed50ed95-for-maintaining-motor-evoked-potentials-d-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 22:10:00 +1200https://doi.org/10.2147/DDDT.S581844Obesity Reduces the Median Effective Dose of Remimazolam in Aged 6–18 Pediatric Patients for Procedural Sedationhttps://www.dovepress.com/obesity-reduces-the-median-effective-dose-of-remimazolam-in-aged-618-p-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 21:40:00 +1200https://doi.org/10.2147/DDDT.S610851GABAA Receptor Modulators as Emerging Therapeutic Agents for Depressive Disordershttps://www.dovepress.com/gabaa-receptor-modulators-as-emerging-therapeutic-agents-for-depressiv-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 21:25:00 +1200https://doi.org/10.2147/DDDT.S608834Modified Single-Side-Lying Quadratus Lumborum Block Combined with Liposomal Bupivacaine versus Transversus Abdominis Plane Block for Post-Cesarean Analgesia: A Randomized Controlled Trialhttps://www.dovepress.com/modified-single-side-lying-quadratus-lumborum-block-combined-with-lipo-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 21:20:00 +1200https://doi.org/10.2147/DDDT.S580472The Impact of Polymers in Amorphous Solid Dispersion on the Bioavailability of Sulfonylureas and Meglitinideshttps://www.dovepress.com/the-impact-of-polymers-in-amorphous-solid-dispersion-on-the-bioavailab-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 21:00:00 +1200https://doi.org/10.2147/DDDT.S610513Celecoxib-Loaded “Nano-in-Nano” Hierarchical Delivery System: Structure-Driven Synergistic Optimization of Diffusion Efficiency and Mechanical Stability for Osteoarthritis Therapyhttps://www.dovepress.com/celecoxib-loaded-nano-in-nano-hierarchical-delivery-system-structure-d-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 20:20:00 +1200https://doi.org/10.2147/DDDT.S601447Association Between Glucagon-Like Peptide-1 Receptor Agonists and Clinical Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Obesityhttps://www.dovepress.com/association-between-glucagon-like-peptide-1-receptor-agonists-and-clin-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 08 Jun 2026 19:40:00 +1200https://doi.org/10.2147/DDDT.S609054Real-World Outcomes of Aflibercept 2 mg Using a Treat-and-Extend Protocol for Neovascular Age-Related Macular Degeneration: A 24-Month Retrospective Study in a Chinese Populationhttps://www.dovepress.com/real-world-outcomes-of-aflibercept-2-mg-using-a-treat-and-extend-proto-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 05 Jun 2026 01:55:00 +1200https://doi.org/10.2147/DDDT.S601668Progress in the Treatment of Ulcerative Colitis by Targeting NLRP3 Inflammasomehttps://www.dovepress.com/progress-in-the-treatment-of-ulcerative-colitis-by-targeting-nlrp3-inf-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 04 Jun 2026 17:25:00 +1200https://doi.org/10.2147/DDDT.S611506Efficacy and Safety of Oteseconazole in Severe Vulvovaginal Candidiasis Categorized by Candida Species and Previous Genital Tract Infection: A Post Hoc Analysis of a Phase 3 Trialhttps://www.dovepress.com/efficacy-and-safety-of-oteseconazole-in-severe-vulvovaginal-candidiasi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 04 Jun 2026 17:15:00 +1200https://doi.org/10.2147/DDDT.S599356Determination of the ED90 of Remimazolam Bolus Dose for Preventing Emergence Delirium in Children with Sevoflurane Anesthesia: A Dose-Finding Study Using Biased-Coin Design Up-and-Down Sequential Methodhttps://www.dovepress.com/determination-of-the-ed90-of-remimazolam-bolus-dose-for-preventing-eme-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 04 Jun 2026 02:40:00 +1200https://doi.org/10.2147/DDDT.S608136An Efficient Pharmacogenomic Assay for Psychotropic Drugs by Multiplex Fluorescence Melting Curve Analysishttps://www.dovepress.com/an-efficient-pharmacogenomic-assay-for-psychotropic-drugs-by-multiplex-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 04 Jun 2026 01:00:00 +1200https://doi.org/10.2147/DDDT.S586665The Natural Compound Cornuside Protects Against Acute Liver Failure Induced by Lipopolysaccharide and D-Galactosaminehttps://www.dovepress.com/the-natural-compound-cornuside-protects-against-acute-liver-failure-in-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 18:20:00 +1200https://doi.org/10.2147/DDDT.S601517A Comprehensive Review of Hedyotis Diffusa Willd–Scutellaria Barbata D. Don Herb Pair in Anti- Hepatocellular Carcinoma Effects and Their Combinatorial Effects and Mechanismshttps://www.dovepress.com/a-comprehensive-review-of-hedyotis-diffusa-willdscutellaria-barbata-d--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 18:00:00 +1200https://doi.org/10.2147/DDDT.S603528