skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

8799

Inhaled insulin: overview of a novel route of insulin administration

Review

(3780) Views  (1223) Full article downloads

Authors: Lucy D Mastrandrea

Published Date January 2010 Volume 2010:6 Pages 47 - 58
DOI: http://dx.doi.org/10.2147/VHRM.S6098

Lucy D Mastrandrea

Department of Pediatrics, School of Medicine and Biochemical Sciences, University at Buffalo, Buffalo, NY, USA

Abstract: Diabetes is a chronic disease characterized by inadequate insulin secretion with resulting hyperglycemia. Diabetes complications include both microvascular and macrovascular disease, both of which are affected by optimal diabetes control. Many individuals with diabetes rely on subcutaneous insulin administration by injection or continuous infusion to control glucose levels. Novel routes of insulin administration are an area of interest in the diabetes field, given that insulin injection therapy is burdensome for many patients. This review will discuss pulmonary delivery of insulin via inhalation. The safety of inhaled insulin as well as the efficacy in comparison to subcutaneous insulin in the various populations with diabetes are covered. In addition, the experience and pitfalls that face the development and marketing of inhaled insulin are discussed.

Keywords: glycemic control, hemoglobin A1c, inhalation, insulin, type 1 diabetes, type 2 diabetes








Readers of this article also read:

Comorbidity and glycemia control among patients with type 2 diabetes in primary care
Analog insulin detemir for patients with type 1 and type 2 diabetes: a review
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Effect of glitazones on the progression of coronary artery disease in type 2 diabetes patients
Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients
Impact of data from recent clinical trials on strategies for treating patients with type 2 diabetes mellitus
Effects of telmisartan on office and 24-hour ambulatory blood pressure: an observational study in hypertensive patients managed in primary care
Current status and future directions in lipid management: emphasizing low-density lipoproteins, high-density lipoproteins, and triglycerides as targets for therapy
Treatment of severe diabetic hypoglycemia with glucagon: an underutilized therapeutic approach
Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?
  • Join ISVH

    Be part of the World's leading experts in vascular health by joining the International Society of Vascular Health (ISVH)

  • Testimonials

    "... I was impressed at the rapidity of publication from submission to final acceptance." Dr Edwin Thrower, PhD, Yale University