Back to Browse Journals » International Journal of Nanomedicine » Volume 3 » Issue 1

Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases

Authors Malgorzata Smola, Thierry Vandamme, Adam Sokolowski

Published Date March 2008 Volume 2008:3(1) Pages 1—19

DOI http://dx.doi.org/10.2147/IJN.S1045

Published 16 March 2008

Malgorzata Smola1,2, Thierry Vandamme1, Adam Sokolowski2

1Université Louis Pasteur, Faculté de Pharmacie, Département de Chimie Bioorganique, Illkirch Graffenstaden, France; 2Wroclaw University of Technology, Faculty of Chemical Engineering, Wroclaw, Poland

Abstract: The purpose of this review is to discuss the impact of nanocarriers administered by pulmonary route to treat and to diagnose respiratory and non respiratory diseases. Indeed, during the past 10 years, the removal of chlorofluorocarbon propellants from industrial and household products intended for the pulmonary route has lead to the developments of new alternative products. Amongst these ones, on one hand, a lot of attention has been focused to improve the bioavailability of marketed drugs intended for respiratory diseases and to develop new concepts for pulmonary administration of drugs and, on the other hand, to use the pulmonary route to administer drugs for systemic diseases. This has led to some marketed products through the last decade. Although the introduction of nanotechnology permitted to step over numerous problems and to improve the bioavailability of drugs, there are, however, unresolved delivery problems to be still addressed. These scientific and industrial innovations and challenges are discussed along this review together with an analysis of the current situation concerning the industrial developments.

Keywords: nanotechnology, nanocarriers, nanoparticle, liposome, lung, pulmonary drug delivery, drug targeting, respiratory disease, microemulsion, bioavailability, micelle

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model

Wang X, Shi L, Tu Q, Wang H, Zhang H, Wang P, Zhang L, Huang Z, Zhao F, Luan H, Wang X

International Journal of Nanomedicine 2015, 10:347-355

Published Date: 6 January 2015

Vincristine sulfate liposomal injection for acute lymphoblastic leukemia [Corrigendum]

Soosay Raj TA, Smith AM, Moore AS

International Journal of Nanomedicine 2013, 8:4705-4706

Published Date: 5 December 2013

Variability in contrast agent uptake by different but similar stem cell types

Ketkar-Atre A, Struys T, Soenen SJ, Lambrichts I, Verfaillie CM, De Cuyper M, Himmelreich U

International Journal of Nanomedicine 2013, 8:4577-4591

Published Date: 29 November 2013

Linear polyethylenimine produced by partial acid hydrolysis of poly(2-ethyl-2-oxazoline) for DNA and siRNA delivery in vitro

Fernandes JC, Qiu X, Winnik FM, Benderdour M, Zhang X, Dai K, Shi Q

International Journal of Nanomedicine 2013, 8:4091-4102

Published Date: 31 October 2013

Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay

Asefnejad A, Khorasani MT, Behnamghader A, Farsadzadeh B, Bonakdar S

International Journal of Nanomedicine 2011, 6:2375-2384

Published Date: 18 October 2011

Microencapsulation of nanoemulsions: novel Trojan particles for bioactive lipid molecule delivery

Li X, Anton N, Ta TMC, Zhao M, Messaddeq N, Vandamme TF

International Journal of Nanomedicine 2011, 6:1313-1325

Published Date: 24 June 2011

Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs

Rao S, Song Y, Peddie F, Evans AM

International Journal of Nanomedicine 2011, 6:1245-1251

Published Date: 20 June 2011

Amino acid-responsive Crohn's disease: a case study

Alvin Stein, Marty Hinz, Thomas Uncini

Clinical and Experimental Gastroenterology 2010, 3:171-177

Published Date: 6 December 2010

Intracellular heavy metal nanoparticle storage: progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy

Tommaso Iannitti, Stefania Capone, Antonietta Gatti, et al

International Journal of Nanomedicine 2010, 5:955-960

Published Date: 15 November 2010

Exacerbation rate, health status and mortality in COPD – a review of potential interventions

Terence AR Seemungal, John R Hurst, Jadwiga A Wedzicha

International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:203-223

Published Date: 29 May 2009