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Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions

Authors Karanikas, Machairiotis N, Zarogoulidis P, Stylianaki, Courcoutsakis N, Mitrakas A, Touzopoulos P, Liratzopoulos, Kouklakis G, Spanoudakis, Polychronidis

Received 28 September 2012

Accepted for publication 6 November 2012

Published 12 December 2012 Volume 2012:5 Pages 433—438

DOI https://doi.org/10.2147/OTT.S38645

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3



Michael Karanikas,1 Nikolaos Machairiotis,2 Paul Zarogoulidis,3,4 Aikaterini Stylianaki,3 Nikolaos Corcoutsakis,5 Alexandros Mitrakas,1 Panagiotis Touzopoulos,1 Nikolaos Lyratzopoulos,1 George Kouklakis,6 Manolis Spanoudakis,7 Alexandros Polychronidis1

1
1st University Surgery Department, 2Surgery Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece; 3Pulmonary Department-Oncology Unit, G. Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 4Pulmonary Department-Interventional Unit, Ruhrland Clinic, University of Duisburg-Essen, Essen, Germany; 5Radiology Department, 6Endoscopy Unit, 7Hematology Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece

Abstract: We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic factor of these lymphomas is considered to be the mutations or allelic losses of the TP53 tumor suppressor gene and the overexpression of the bcl-2 oncogene. Gastrointestinal stromal tumors are mesenchymal tumors, which are typically defined by the expression of c-KIT (CD117) and CD34 genes in the tumor cells. Although there are references to dispersants in the literature about patients with both non-Hodgkin lymphoma and gastrointestinal stromal tumors, there is no common molecular pathway between these two diseases. In conclusion, there is no indication that these two neoplasms are relevant on a molecular basis.

Keywords: hematological malignacies, mesenchymal cells, gastrointestinal cancer

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