Back to Journals » OncoTargets and Therapy » Volume 5
Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions
Authors Karanikas, Machairiotis N, Zarogoulidis P, Stylianaki, Courcoutsakis N, Mitrakas A, Touzopoulos P, Liratzopoulos, Kouklakis G, Spanoudakis, Polychronidis
Received 28 September 2012
Accepted for publication 6 November 2012
Published 12 December 2012 Volume 2012:5 Pages 433—438
DOI https://doi.org/10.2147/OTT.S38645
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Michael Karanikas,1 Nikolaos Machairiotis,2 Paul Zarogoulidis,3,4 Aikaterini Stylianaki,3 Nikolaos Corcoutsakis,5 Alexandros Mitrakas,1 Panagiotis Touzopoulos,1 Nikolaos Lyratzopoulos,1 George Kouklakis,6 Manolis Spanoudakis,7 Alexandros Polychronidis1
11st University Surgery Department, 2Surgery Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece; 3Pulmonary Department-Oncology Unit, G. Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 4Pulmonary Department-Interventional Unit, Ruhrland Clinic, University of Duisburg-Essen, Essen, Germany; 5Radiology Department, 6Endoscopy Unit, 7Hematology Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
Abstract: We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic factor of these lymphomas is considered to be the mutations or allelic losses of the TP53 tumor suppressor gene and the overexpression of the bcl-2 oncogene. Gastrointestinal stromal tumors are mesenchymal tumors, which are typically defined by the expression of c-KIT (CD117) and CD34 genes in the tumor cells. Although there are references to dispersants in the literature about patients with both non-Hodgkin lymphoma and gastrointestinal stromal tumors, there is no common molecular pathway between these two diseases. In conclusion, there is no indication that these two neoplasms are relevant on a molecular basis.
Keywords: hematological malignacies, mesenchymal cells, gastrointestinal cancer
© 2012 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.