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Vascular Health and Risk Management
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Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review
(1801) Article views
Authors: Steve Fordan, Philip Raskin
Published Date February 2009 , Volume 2009:5
Steve Fordan, Philip Raskin
Department of Medicine, Division, of Endocrinology, University of Texas, Southwestern Medical Center, Dallas, TX, USA
Abstract: The insulin analogs lispro, aspart, and glulisine are the only commercially available rapid-acting insulins to treat diabetes. We review the evidence for treating hyperglycemia, using insulin, and specifically using rapid-acting analogs in diabetic individuals, on the prevention of vascular events. We review the beneficial effects of insulin on the vascular system, which include vasodilation and anti-inflammatory actions. The effects of treating hyperglycemia and intensive blood glucose control on vascular outcomes are reviewed.
Keywords: lispro, aspart, glulisine, nitric oxide synthetase, nuclear factor kappa B
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