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A Response to Article “Do Mesenchymal Stem Cells Influence Keloid Recurrence?” [Response to Letter]
Authors Nang'ole WF
Received 23 January 2023
Accepted for publication 26 January 2023
Published 31 January 2023 Volume 2023:16 Pages 3—4
Wanjala Ferdinand Nang’ole
Department of Surgery, University of Nairobi, Nairobi, Kenya
Correspondence: Wanjala Ferdinand Nang’ole, Department of Surgery, University of Nairobi, PO Box 30197-00100, Nairobi, Kenya, Tel +254-71-4342-214, Email [email protected]
Corrigendum for this paper has been published.
Dear editor
In their recent perspective, Noviantari et al1 review our recent publication titled “Do Mesenchymal Stem Cells Influence Keloid Recurrence?” and highlight that we failed to use The International Society for Cellular Therapy (ISCT) three prerequisites before designating cells as MSCs. While we are in agreement with the ISCT criteria for the characterization of MSCs (with flow cytometry, adhesion to the plastic surface and differentiation ability), this was a challenge for us in this study. As this was a longitudinal prospective study of 61 keloid and a control group of 32 patients, fulfilling all three ISCT criteria would require a lot of technical support and would also be very expensive beyond the budget limit of the study.
Noviantari et al1 also mention that they did not find any histopathological analysis. The diagnosis of keloid was made through both clinical examination and confirmed by histology of the specimens. A qualified dermatopathologist analysed all the specimens and confirmed whether they were keloids or not. For normal skin, this was taken from patients undergoing elective surgical procedures with no skin pathologies.
The current challenge for clinicians and immunologists is to find a phenotypic classification for MSCs that is simple enough and yet specific and sensitive to be useful in a clinical setting. Studies using modern analytical approaches including single cell RNA sequencing support incorporating new findings to the ISCT criteria to accurately define stemness and MSCs.
Disclosure
The author reports no conflicts of interest in this communication.
Reference
1. Noviantari A, Dany F, Intan PR. A response to article “Do mesenchymal stem cells influence keloid recurrence?” [Letter]. Stem Cells Cloning. 2023;16:1–2. doi:10.2147/SCCAA.S403167
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