RETRACTED ARTICLE: Downregulation of MMSET impairs breast cancer proliferation and metastasis through inhibiting Wnt/β-catenin signaling

This paper has been retracted.

Zhao X, Xie T, Zhao W, Cai W, Su X. Onco Targets Ther. 2019;12:1965–1977.

We, the Editor and Publisher of the journal OncoTargets and Therapy are retracting the published article.

Following publication of the article, concerns were raised regarding the duplication of images from Figure 1 with images from unrelated articles. Specifically,

• The images for Figure 1C, Patient 2 and Patient 3, ANT, have been duplicated with the images for Figure 1D, Clinical stage I, 200X and Normal, 400X, respectively from Zhao X, Xie T, Dai T, et al. CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a. Mol Cancer Res. 2018;16(10):1512–1522. https://doi.org/10.1158/1541-7786.MCR-18-0157.
• The image for Figure 1D, Clinical stage III, 200x, has been duplicated with the image for Figure 1C, Tumor, 200X, from Wang X, Lin C, Zhao X, et al. Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor. Mol Cancer. 2014;13:106. https://doi.org/10.1186/1476-4598-13-106.
• The images for Figure 2C, ZR-75-30, siMMSET and Figure 4C, ZR-75-30, siMMSET+pcDNA3.1, have been duplicated.
• The images for Figure 2C, MDA-MB-231, siCon and Figure 4C, ZR-75-30, siMMSET, have been duplicated.
• The images for Figure 3B, MDA-MB-231, siCon and Figure 4E, MDA-MB-231, siMMSET+MMSET, have been duplicated.

The corresponding author did not respond to our queries and was unable to provide a satisfactory explanation for how the images came to be duplicated or provide satisfactory original data for the study. As verifying the validity of published work is core to the integrity of the scholarly record, the Publisher and Editor requested to retract the article and the corresponding author was notified of this.

We have been informed in our decision-making by our editorial policies and COPE guidelines.

The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.