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Endoglin: a critical mediator of cardiovascular health
Authors Kapur NK, Morine KJ, Letarte M
Received 11 September 2012
Accepted for publication 9 February 2013
Published 6 May 2013 Volume 2013:9 Pages 195—206
DOI https://doi.org/10.2147/VHRM.S29144
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Navin K Kapur,1 Kevin J Morine,1 Michelle Letarte2,3
1Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA; 2Molecular Structure and Function Program, Hospital for Sick Children, 3The Heart and Stroke Foundation Richard Lewar Centre of Excellence, and the Department of Immunology, University of Toronto, Toronto, Ontario, Canada
Abstract: Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFß) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic telangiectasia, pre-eclampsia, and cardiac fibrosis, have now been associated with endoglin. Given the central role of the TGFß superfamily in multiple disease conditions, this review provides a detailed update on endoglin as an evolving therapeutic target in the management of cardiovascular disease.
Keywords: endoglin, transforming growth factor beta, vascular, cardiac remodeling
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