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Noteworthy Comment: Cancer is a leading killer of human beings. The discovery of anticancer drugs is heavily dependent on the use of animals. This paper hightlights the use and limitations of animal models in cancer research. Mouse cancer models are most commonly used for cancer study and they have revolutionized our understanding on gene and protein functions and the pathways in vivo. Xenografts, chemically-induced or genetically induced mouse cancer models are the most used rodent cancer models. The authors have mentioned that companion animals with spontaneous neoplasms are still underexploited tool to make rapid advances in human and veterinary cancer therapies. Companion animals have relatively high incidence of cancers that have similar biological
behavior, response to therapy, and comparable responses to cytotoxic agents as people. However, animal cancer models have intrinsic limitations and this makes the translation from preclinical model to humans difficult. We may need to identify better models for cancer study or use a combination of models to cross-validate the data.

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Animal models and therapeutic molecular targets of cancer: utility and limitations

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