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Review

Noteworthy comment: Despite the availability of several classes of drugs, migraine remains a difficult condition to treat effectively. This review provides an overview of three compounds : calcitonin gene related peptide (CGRP), brain natriuretic peptide (BNP) and ATP, whose intricate interactions contributes to the regulation of those neurons in the trigeminal system which generate the severe pain and other symptoms of migraine. Developing our knowledge of these compounds could lead to the generation of increasingly more effective drugs for the treatment of the condition.

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Role of calcitonin gene-related peptide and brain natriuretic peptide to modulate the excitability state of trigeminal neurons: relevance to migraine pathology and treatment

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