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Original Research

Noteworthy comment: This study provides evidence that activation of natural killer cells can be used as an early predictor of response in patients with rheumatoid arthritis treated with rituximab. Activation of natural killer cells, measured 3 months after the first rituximab course, significantly correlated with clinical response at 6 months and 1 year, independently from other clinical variables. These results support the current scientific thought that natural killer cells may be effectors of antibody dependent cell mediated cytotoxicity induced by monoclonal antibody therapies, such as rituximab.

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NK cell count as predictor of clinical response in patients with rheumatoid arthritis treated with rituximab

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