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Papers published by Professor Shu-Feng Zhou:
Coffee and Caffeine Potentiate the Antiamyloidogenic Activity of Melatonin via Inhibition of Aβ Oligomerization and Modulation of theTau-Mediated Pathway in N2a/APP Cells [Retraction]
Zhang L, Zhou Z, Wang Z, Du Y, He Z, Cao C, Zhou S
Drug Design, Development and Therapy 2022, 16:4041-4042
Published Date: 21 November 2022
Induction of Apoptosis and Autophagy via sirtuin1- and PI3K/Akt/mTOR-Mediated Pathways by Plumbagin in Human Prostate Cancer Cells [Retraction]
Zhou Z, Li X, He Z, Pan S, Yang Y, Zhang X, Chow K, Yang T, Qiu J, Zhou Q, Tan J, Wang D, Zhou S
Drug Design, Development and Therapy 2022, 16:2437-2438
Published Date: 29 July 2022
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Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum]
Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sanjeev S, Zhou SF, Sasidharan S, Kanwar RK
Drug Design, Development and Therapy 2017, 11:2683-2684
Published Date: 12 September 2017
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Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Zhou SF, Qiu JX
Drug Design, Development and Therapy 2015, 9:5511-5551
Published Date: 5 October 2015
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Repurposing paclitaxel for the treatment of fibrosis: indication discovery for existing drugs
Chen XW, Duan W, Zhou SF
Drug Design, Development and Therapy 2015, 9:4869-4871
Published Date: 7 September 2015
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High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in bronchoalveolar lavage fluid in patients with ventilator-associated pneumonia
Yang XJ, Wang YB, Zhou ZW, Wang GW, Wang XH, Liu QF, Zhou SF, Wang ZH
Drug Design, Development and Therapy 2015, 9:4883-4896
Published Date: 24 August 2015
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High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in cerebrospinal fluid samples from patients with purulent meningitis
Liu A, Wang C, Liang Z, Zhou ZW, Wang L, Ma Q, Wang G, Zhou SF, Wang Z
Drug Design, Development and Therapy 2015, 9:4417-4429
Published Date: 7 August 2015
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Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study
Niu NK, Yin JJ, Yang YX, Wang ZL, Zhou ZW, He ZX, Chen XW, Zhang XJ, Duan W, Yang TX, Zhou SF
Drug Design, Development and Therapy 2015, 9:4441-4470
Published Date: 7 August 2015
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A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver
He WH, Shi F, Zhou ZW, Li BM, Zhang KH, Zhang XH, Ouyang CH, Zhou SF, Zhu X
Drug Design, Development and Therapy 2015, 9:3989-4104
Published Date: 31 July 2015
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Controllable drug uptake and nongenomic response through estrogen-anchored cyclodextrin drug complex
Yin JJ, Shumyak SP, Burgess C, Zhou ZW, He ZX, Zhang XJ, Pan ST, Yang T, Duan W, Qiu JX, Zhou SF
International Journal of Nanomedicine 2015, 10:4717-4730
Published Date: 27 July 2015
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Functional magnetic resonance imaging is a powerful approach to probing the mechanism of action of therapeutic drugs that act on the central nervous system
Zhou SF
Drug Design, Development and Therapy 2015, 9:3863-3865
Published Date: 23 July 2015
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Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice
Wang YY, Zhang CY, Ma YQ, He ZX, Zhe H, Zhou SF
Drug Design, Development and Therapy 2015, 9:3163-3178
Published Date: 22 June 2015
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Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis
Chen XW, Zhou SF
Drug Design, Development and Therapy 2015, 9:2941-2946
Published Date: 8 June 2015
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Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer
Ren T, Shan J, Li M, Qing Y, Qian C, Wang G, Li Q, Lu G, Li C, Peng Y, Luo H, Zhang S, Yang Y, Cheng Y, Wang D, Zhou SF
Drug Design, Development and Therapy 2015, 9:2887-2910
Published Date: 8 June 2015
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Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling
Kanwar JR, Samarasinghe RM, Kumar K, Arya R, Sharma S, Zhou SF, Sasidharan S, Kanwar RK
Drug Design, Development and Therapy 2015, 9:2927-2940
Published Date: 5 June 2015
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Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance
Wang G, Liu Y, Qiu P, Zhou SF, Xu L, Wen P, Wen J, Xiao X
Drug Design, Development and Therapy 2015, 9:2839-2846
Published Date: 2 June 2015
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A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells
Zhou YF, Li JM, Lu F, Deng JJ, Zhang JH, Fang PJ, Peng XS, Zhou SF
Drug Design, Development and Therapy 2015, 9:2635-2645
Published Date: 14 May 2015
![Video](assets/img/article_icons/video.png)
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Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity
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![](http://img.youtube.com/vi/DvneqcuecK4/1.jpg)
Zhang Y, Zhou ZW, Jin H, Hu C, He ZX, Yu ZL, Ko KM, Yang T, Zhang X, Pan SY, Zhou SF
Drug Design, Development and Therapy 2015, 9:2001-2027
Published Date: 9 April 2015
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Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma
Li C, Xiong Y, Yang X, Wang L, Zhang S, Dai N, Li M, Ren T, Yang Y, Zhou SF, Gan L, Wang D
Drug Design, Development and Therapy 2015, 9:1773-1783
Published Date: 24 March 2015
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Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives
Gao JS, Tong XP, Chang YQ, He YX, Mei YD, Tan PH, Guo JL, Liao GC, Xiao GK, Chen WM, Zhou SF, Sun PH
Drug Design, Development and Therapy 2015, 9:1743-1759
Published Date: 23 March 2015
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The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells
Li JP, Yang YX, Liu QL, Pan ST, He ZX, Zhang X, Yang T, Chen XW, Wang D, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1627-1652
Published Date: 16 March 2015
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Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1601-1626
Published Date: 16 March 2015
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Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway
Niu NK, Wang ZL, Pan ST, Ding HQ, Au GHT, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1555-1584
Published Date: 12 March 2015
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Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells
Zhou ZW, Li XX, He ZX, Pan ST, Yang Y, Zhang X, Chow K, Yang T, Qiu JX, Zhou Q, Tan J, Wang D, Zhou SF
Drug Design, Development and Therapy 2015, 9:1511-1554
Published Date: 12 March 2015
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Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells
Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Pan SY, Chen XW, Zhou SF
Drug Design, Development and Therapy 2015, 9:1293-1318
Published Date: 2 March 2015
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Hsa-microRNA-181a is a regulator of a number of cancer genes and a biomarker for endometrial carcinoma in patients: a bioinformatic and clinical study and the therapeutic implication
He S, Zeng S, Zhou ZW, He ZX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1103-1175
Published Date: 18 February 2015
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A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis
Han XD, Zhou ZW, Yang W, Ye HC, Xu YZ, Huang YF, Zhang T, Zhou SF
Drug Design, Development and Therapy 2015, 9:1063-1102
Published Date: 18 February 2015
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Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach
![](cr_data/cache/submission_images/s76000/76021/figure_2_200_200_90.jpg)
Pan ST, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:937-968
Published Date: 17 February 2015
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Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells
Wang YY, Yang YX, Zhao R, Pan ST, Zhe H, He ZX, Duan W, Zhang X, Yang TX, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:993-1026
Published Date: 17 February 2015
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Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice
Zhu PL, Pan SY, Zhou SF, Zhang Y, Wang XY, Sun N, Chu ZS, Yu ZL, Ko KM
Drug Design, Development and Therapy 2015, 9:923-935
Published Date: 17 February 2015
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The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells
Li JP, Yang YX, Liu QL, Zhou ZW, Pan ST, He ZX, Zhang X, Yang T, Pan SY, Duan W, He SM, Chen XW, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:1027-1062
Published Date: 17 February 2015
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Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer
Qing Y, Li Q, Ren T, Xia W, Peng Y, Liu GL, Luo H, Yang YX, Dai XY, Zhou SF, Wang D
Drug Design, Development and Therapy 2015, 9:901-909
Published Date: 16 February 2015
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Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies
Qiu JX, Zhou ZW, He ZX, Zhang X, Zhou SF, Zhu S
Drug Design, Development and Therapy 2015, 9:841-866
Published Date: 16 February 2015
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Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells
Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:537-560
Published Date: 17 January 2015
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Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
Wang F, Li H, Yan XG, Zhou ZW, Yi ZG, He ZX, Pan ST, Yang YX, Wang ZZ, Zhang X, Yang T, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:575-601
Published Date: 17 January 2015
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Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells
Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Wang NJ, Zhao RJ, Zhou SF
Drug Design, Development and Therapy 2015, 9:487-508
Published Date: 14 January 2015
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Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells
Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang ZX, Zhang XJ, Duan W, Yang TX, Qiu JX, Zhou SF
Drug Design, Development and Therapy 2015, 9:425-464
Published Date: 9 January 2015
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Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells
Qui JX, Zhou ZW, He ZX, Zhao RJ, Zhang X, Yang L, Zhou SF, Mao ZF
Drug Design, Development and Therapy 2015, 9:349-417
Published Date: 7 January 2015
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RETRACTED ARTICLE: Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells
Zhang LF, Zhou ZW, Wang ZH, Du YH, He ZX, Cao CH, Zhou SF
Drug Design, Development and Therapy 2015, 9:241-272
Published Date: 24 December 2014
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An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides
![](cr_data/cache/submission_images/s72000/72892/11_sep_2014_figure_1_200_200_90.jpg)
Cheng J, Zhou ZW, Sheng HP, He LJ, Fan XW, He ZX, Sun T, Zhang X, Zhao RJ, Gu L, Cao CH, Zhou SF
Drug Design, Development and Therapy 2015, 9:33-78
Published Date: 17 December 2014
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Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
He JL, Zhou ZW, Yin JJ, He CQ, Zhou SF, Yu Y
Drug Design, Development and Therapy 2015, 9:127-146
Published Date: 17 December 2014
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Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway
Ren T, Shan J, Qing Y, Qian C, Li Q, Lu G, Li M, Li C, Peng Y, Luo H, Zhang S, Zhang W, Wang D, Zhou SF
Drug Design, Development and Therapy 2014, 8:2517-2529
Published Date: 12 December 2014
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Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study
Su JH, Chang C, Xiang Q, Zhou ZW, Luo R, Yang L, He ZX, Yang HT, Li J, Bei Y, Xu JM, Zhang MJ, Zhang QH, Su ZJ, Huang YD, Pang JY, Zhou SF
Drug Design, Development and Therapy 2014, 8:2555-2602
Published Date: 12 December 2014
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Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts
Zhu Y, Cheng M, Yang Z, Zeng CY, Chen J, Xie Y, Luo SW, Zhang KH, Zhou SF, Lu NH
Drug Design, Development and Therapy 2014, 8:2449-2462
Published Date: 9 December 2014
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Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients
Zhang ZW, Zhong X, Ji HR, Tang ZB, Bai JP, Yao MM, Hou JL, Zheng MH, Wood D, Sun JZ, Zhou SF, Liu AB
Drug Design, Development and Therapy 2014, 8:2439-2448
Published Date: 5 December 2014
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Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties
Wang YY, Yang YX, Zhe H, He ZX, Zhou SF
Drug Design, Development and Therapy 2014, 8:2075-2088
Published Date: 23 October 2014
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Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors
Xu WT, Yang Z, Zhou SF, Lu NH
Drug Design, Development and Therapy 2014, 8:1745-1751
Published Date: 6 October 2014
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Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain
Shan LX, Sun PH, Guo BQ, Xu XJ, Li ZQ, Sun JZ, Zhou SF, Chen WM
Drug Design, Development and Therapy 2014, 8:1515-1525
Published Date: 24 September 2014
![Video](assets/img/article_icons/video.png)
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Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice
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Zhang Y, Pan SY, Zhou SF, Wang XY, Sun N, Zhu PL, Chu ZS, Yu ZL, Ko KM
Drug Design, Development and Therapy 2014, 8:1429-1439
Published Date: 19 September 2014
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A comparative study of three ternary complexes prepared in different mixing orders of siRNA/redox-responsive hyperbranched poly (amido amine)/hyaluronic acid
Chen CJ, Zhao ZX, Wang JC, Zhao EY, Gao LY, Zhou SF, Liu XY, Lu WL, Zhang Q
International Journal of Nanomedicine 2012, 7:3837-3849
Published Date: 18 July 2012