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Comparing Analgesic Efficacy of Regional Block Techniques After Laparoscopic Liver Resection: In Reply [Response to Letter]
Received 1 February 2022
Accepted for publication 11 February 2022
Published 3 March 2022 Volume 2022:15 Pages 663—664
RyungA Kang, Justin Sangwook Ko
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Correspondence: Justin Sangwook Ko, Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon ro, Gangnam gu, Seoul, 06351, Korea, Tel +82 2-3410-2454, Fax +82 2-3410-0361, Email [email protected]
View the original paper by Prof. Dr. Kang and colleagues
This is in response to the Letter to the Editor
Dear editor
We thank Dr. Nong He et al for their comments on our study. First, we agree that the distinction is important when designing, or interpreting the results of clinical trials. However, we disagree that the minimal clinically important difference (MCID) should dictate the effect size used in a sample size calculation for a clinical trial.1 The chosen effect size should be clinically or scientifically meaningful, but it need not be the MCID.2 In addition, the recommended MCIDs of 10 mg IV morphine reduction for 24 h is for total hip arthroplasty or total knee arthroplasty,3 not for liver resection.
Second, most patients complained of severe abdominal pain or discomfort when they were admitted to the PACU (ie, at emergence) which led to demands for additional opioid analgesics. So, the highest pain score was mostly detected at the time of PACU admission as shown in Figure 2,4
Figure 2 Numeric rating scale (NRS) scores at rest for the two groups within 72 hours postoperatively. P values result from a Bonferroni correction for multiple comparisons. Abbreviations: ESP, erector spinae plane; QL, quadratus lumborum. Notes: Reproduced from: Kang R, Lee S, Kim GS, et al. Comparison of Analgesic Efficacy of Erector Spinae Plane Block and Posterior Quadratus Lumborum Block in Laparoscopic Liver Resection: A Randomized Controlled Trial. J Pain Res. 2021;14:3791–3800. doi: 10.2147/JPR.S343366.4 © 2021 Kang et al. Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). |
In our institution, postoperative pain management in the general ward was performed by the surgical team. We agree that postoperative pain management should be more refined to improve patient recovery. We also agree that repeated measurement of the QoR-15 questionnaire might be better to elucidate the quality of recovery between two peripheral nerve blocks. However, the QoR-15 score was the secondary outcome of this study, and we were more focused on the primary outcome (ie, cumulative opioid consumption) under the constraints such as limitations in time and manpower.
Disclosure
The authors report no conflicts of interest for this communication.
References
1. Myles PS, Myles DB. Conflating effect size and minimal clinically important difference. Comment on Br J Anaesth 2021; 126: 1029–37. Br J Anaesth. 2022;128(1):e1–e2. doi:10.1016/j.bja.2021.09.018
2. Walder B, Maillard J, Lubbeke A. Minimal clinically important difference: a novel approach to measure changes in outcome in perioperative Medicine. Eur J Anaesthesiol. 2015;32(2):77–78. doi:10.1097/EJA.0000000000000147
3. Laigaard J, Pedersen C, Ronsbo TN, Mathiesen O, Karlsen APH. Minimal clinically important differences in randomised clinical trials on pain management after total hip and knee arthroplasty: a systematic review. Br J Anaesth. 2021;126(5):1029–1037. doi:10.1016/j.bja.2021.01.021
4. Kang R, Lee S, Kim GS, et al. Comparison of Analgesic Efficacy of Erector Spinae Plane Block and Posterior Quadratus Lumborum Block in Laparoscopic Liver Resection: A Randomized Controlled Trial. J Pain Res. 2021;14:3791–3800. doi:10.2147/JPR.S343366
5. Kang R, Chin KJ, Gwak MS, et al. Bilateral single-injection erector spinae plane block versus intrathecal morphine for postoperative analgesia in living donor laparoscopic hepatectomy: a randomized non-inferiority trial. Reg Anesth Pain Med. 2019:
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