RETRACTED ARTICLE: JAK-STAT Domain Enhanced MUC1-CAR-T Cells Induced Esophageal Cancer Elimination

This paper has been retracted.

Zhang H, Zhao H, He X, Xi F, Liu J. Cancer Manag Res. 2020;12:9813–9824.

We, the Editor and Publisher of the journal Cancer Management and Research are retracting the published article.

Following publication of the article, concerns were raised regarding the duplication of images from Figures 2, 4 and 5 with images from unrelated articles. Specifically,

• The images for Figure 2J, Mock, BB-z and δIL2RBB-z have been duplicated with the images for Figure 3G, UTD, 20min; EGFR-CAT T, 4h and EGFR-CAR T, 12h, respectively from Li H, Huang Y, Jiang DQ, et al. Antitumor activity of EGFR-specific CAR T cells against non-small-cell lung cancer cells in vitro and in mice. Cell Death Dis. 2018;9:177. https://doi.org/10.1038/s41419-017-0238-6.
• The images for Figure 4A, have been duplicated with the images for Figure 6E from Mohammed S, Sukumaran S, Bajgain P, et al. Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer. Molecular Therapy. 2017;25;(1):249–258. https://doi.org/10.1016/j.ymthe.2016.10.016.
• The images for Figure 5A, have been duplicated with the images for Figure 6E, PBS and Anti-control, ZO-1, from Zhou W, Fong MY, Min Y, et al. Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis. Cancer Cell. 2014;25(4):501–515. https://doi.org/10.1016/j.ccr.2014.03.007.

The corresponding author did not respond to our queries and was unable to provide a satisfactory explanation for how the images came to be duplicated or provide satisfactory original data for the study. As verifying the validity of published work is core to the integrity of the scholarly record, the Publisher and Editor requested to retract the article and the corresponding author was notified of this.

We have been informed in our decision-making by our editorial policies and COPE guidelines.

The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.