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Repeated renal infarction in native and transplanted kidneys due to left ventricular thrombus formation caused by antiphospholipid antibody syndrome
Authors Scully P, Leckstroem D, McGrath A, Chambers J, Goldsmith D
Received 18 October 2012
Accepted for publication 13 November 2012
Published 20 January 2013 Volume 2013:6 Pages 7—12
DOI https://doi.org/10.2147/IMCRJ.S39301
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Paul Scully,1 Daniel C Leckstroem,1 Andrew McGrath,2 John Chambers,3 David J Goldsmith1
1Nephrology Department, 2Radiology Department, 3Cardiology Department, King's Health Partners, Academic Health Sciences Centre, London, United Kingdom
Abstract: Antiphospholipid syndrome can be a feature of several underlying conditions, such as lupus, but it can also occur idiopathically. Diagnosis usually comes after investigation of recurrent venous or arterial thromboses, emboli, or hypertension/proteinuria where the kidney is involved and is usually confirmed by laboratory testing. We describe a case of a man with a myocardial infarction who developed mural thrombus in an akinetic left ventricular segment but then who recurrently embolized first to one of his native kidneys and then later to a transplanted kidney. Although the clinical behavior was typical of antiphospholipid syndrome, it took numerous laboratory assays over many years until finally the problem was confirmed and life-long warfarin therapy instituted.
Keywords: antiphospholipid therapy, emboli, infarction, kidney, kidney transplant
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