Zhou R, Fu L, Liu S, Gao S, Zhao Z, Jiang W, Liu L, Ren W, Xiang D, You X, Tang C, Zhou Y, Song Y, Xie J, Xie L, Yu R, Zhang X, Zhou D, Han J, Xia L, Xiong L

Drug Design, Development and Therapy 2024, 18:1907-1915

Published Date: 29 May 2024

Review

Neurovascular Adverse Effects of Sars-Cov-2 Vaccination

Panos LD, Bargiotas P, Hadjigeorgiou G, Panos GD

Drug Design, Development and Therapy 2024, 18:1891-1905

Published Date: 30 May 2024

Original Research

Shen’ge Formula Protects Cardiac Function in Rats with Pressure Overload-Induced Heart Failure

Qiu B, Qiao S, Shi X, Shen L, Deng B, Ma Z, Zhou D, Wei Y

Drug Design, Development and Therapy 2024, 18:1875-1890

Published Date: 30 May 2024

Original Research

Effect of Preadministration of Nalmefene on Sufentanil-Induced Cough During Induction of General Anesthesia in Patients Undergoing Breast Surgery: A Double-Blind Randomized Controlled Trial

Xie W, He H, Hong J, Feng C, Li W, Li Y

Drug Design, Development and Therapy 2024, 18:1865-1874

Published Date: 29 May 2024

Original Research

Evaluation of Drug-Drug Interaction Between Henagliflozin and Hydrochlorothiazide in Healthy Chinese Volunteers

Chen Q, Yu C, Wu Q, Song R, Liu Y, Feng S, Yu C, Jia J

Drug Design, Development and Therapy 2024, 18:1855-1864

Published Date: 29 May 2024

Original Research

Parabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity Against Colon Tumors by Modulating CXCL10 and CD8+ T Cells

Liang R, Li P, Yang N, Xiao X, Gong J, Zhang X, Bai Y, Chen Y, Xie Z, Liao Q

Drug Design, Development and Therapy 2024, 18:1833-1853

Published Date: 28 May 2024

Original Research

Assessing the Impact of Morphine on Adverse Outcomes in ACS Patients Treated with P2Y12 Inhibitors: Insights from Multiple Real-World Evidence

Ouyang C, Meng C, Li F, Nie S, Gong L, Cao Y, Yuan H, Feng Z

Drug Design, Development and Therapy 2024, 18:1811-1819

Published Date: 27 May 2024

Clinical Trial Report

Effect of Oxycodone-Based Multimodal Analgesia on Visceral Pain After Major Laparoscopic Gastrointestinal Surgery: A Randomised, Double-Blind, Controlled Trial

Yang GW, Cheng H, Song XY, Yang YF, Liu H, Ji FH, Peng K

Drug Design, Development and Therapy 2024, 18:1799-1810

Published Date: 27 May 2024

Original Research

Dexmedetomidine’s Effects on the Livers and Kidneys of Rats with Pancreatic Ischemia-Reperfusion Injury

Bostancı H, Erel S, Küçük A, Kip G, Sezen ŞC, Gokgoz S, Atlı M, Aktepe F, Dikmen K, Arslan M, Kavutçu M

Drug Design, Development and Therapy 2024, 18:1785-1797

Published Date: 27 May 2024

Review

Population Pharmacokinetic Models of Venetoclax in Hematologic Malignancies: A Systematic Review

Zhao Y, Guo N, Zhu Y, Shang J, Chen J, Luo X, Liu Y, Zhang X, Huang L

Drug Design, Development and Therapy 2024, 18:1771-1784

Published Date: 27 May 2024

Original Research

Andrographolide Attenuates NLRP3 Inflammasome Activation and Airway Inflammation in Exacerbation of Chronic Obstructive Pulmonary Disease

Yu Y, Miao TW, Xiao W, Mao B, Du LY, Wang Y, Fu JJ

Drug Design, Development and Therapy 2024, 18:1755-1770

Published Date: 24 May 2024

Clinical Trial Report

Comparison of Remimazolam Tosilate and Propofol Sedation on the Early Postoperative Quality of Recovery in Patients Undergoing Day Surgery: A Prospective Randomized Controlled Trial

Zhang L, Wang Z, Liu Y, Zhang X, Wu Y

Drug Design, Development and Therapy 2024, 18:1743-1754

Published Date: 23 May 2024

Clinical Trial Report

Effect of Continuous Infusion of Different Doses of Esketamine on the Bispectral Index During Sevoflurane Anesthesia: A Randomized Controlled Trial

Ren L, Yang J, Li Y, Wang Y

Drug Design, Development and Therapy 2024, 18:1727-1741

Published Date: 23 May 2024

Review

Imrecoxib: Advances in Pharmacology and Therapeutics

Wang YH, Zhu LL, Li TL, Zhou Q

Drug Design, Development and Therapy 2024, 18:1711-1725

Published Date: 22 May 2024

Original Research

Magnolia Officinalis Alcohol Extract Alleviates the Intestinal Injury Induced by Polygala Tenuifolia Through Regulating the PI3K/AKT/NF-κB Signaling Pathway and Intestinal Flora

Liu S, Yang D, Li W, Chen Q, Lu D, Xiong L, Wu J, Ao H, Huang L

Drug Design, Development and Therapy 2024, 18:1695-1710

Published Date: 22 May 2024

Review

Pristimerin Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review

Sun J, Tian Z, Wu J, Li J, Wang Q, Huang S, Wang M

Drug Design, Development and Therapy 2024, 18:1673-1694

Published Date: 18 May 2024

Original Research

Integrated Approaches Revealed the Therapeutic Mechanisms of Zuojin Pill Against Gastric Mucosa Injury in a Rat Model with Chronic Atrophic Gastritis

Chen L, He T, Wang R, Liu H, Wang X, Li H, Jing M, Zhou X, Wei S, Zou W, Zhao Y

Drug Design, Development and Therapy 2024, 18:1651-1672

Published Date: 17 May 2024

Review

Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis

Deng J, Liu J, Chen W, Liang Q, He Y, Sun G

Drug Design, Development and Therapy 2024, 18:1627-1650

Published Date: 17 May 2024

Original Research

Preoperative Anxiolytic and Sedative Effects of Intranasal Remimazolam and Dexmedetomidine: A Randomized Controlled Clinical Study in Children Undergoing General Surgeries

Cai YH, Wang CY, Fang YB, Ma HY, Gao YQ, Wang Z, Wu J, Lin H, Liu HC

Drug Design, Development and Therapy 2024, 18:1613-1625

Published Date: 17 May 2024

Clinical Trial Report

Low-Dose Alfentanil Inhibits Sufentanil-Induced Cough During Anesthesia Induction: A Prospective, Randomized, Double-Blind Study

Xu Q, Zou X, Wu J, Duan G, Lan H, Wang L

Drug Design, Development and Therapy 2024, 18:1603-1612

Published Date: 17 May 2024

Original Research

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis

Liu L, Zhang B, Zhou Z, Yang J, Li A, Wu Y, Peng Z, Li X, Liu Z, Leng X, Zhao C, Dong H, Zhao W

Drug Design, Development and Therapy 2024, 18:1583-1602

Published Date: 15 May 2024

Original Research

Comparative Bleeding Risk of Brand Vs Generic Rivaroxaban in Elderly Inpatients with Atrial Fibrillation

Chen G, Chen J, Zhao Q, Zhu Y

Drug Design, Development and Therapy 2024, 18:1573-1582

Published Date: 13 May 2024

Review

A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds

Nazir MS, Ahmad M, Aslam S, Rafiq A, Al-Hussain SA, Zaki MEA

Drug Design, Development and Therapy 2024, 18:1547-1571

Published Date: 8 May 2024

Original Research

A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK

Ma Y, Cui Q, Zhu W, Wang M, Zhai L, Hu W, Liu D, Liu M, Li Y, Li M, Han W

Drug Design, Development and Therapy 2024, 18:1531-1546

Published Date: 7 May 2024

Letter

Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy: A Randomized Controlled Trial [Letter]

Xue B

Drug Design, Development and Therapy 2024, 18:1529-1530

Published Date: 6 May 2024

Original Research

ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis

Wang K, Kou Y, Rong X, Wei L, Li J, Liu H, Li M, Song H

Drug Design, Development and Therapy 2024, 18:1515-1528

Published Date: 6 May 2024

Original Research

Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway

Yang YY, Deng RR, Xiang DX

Drug Design, Development and Therapy 2024, 18:1499-1514

Published Date: 2 May 2024

Letter

Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease [Letter]

Yulion R, Andriani L, Aliyah SH

Drug Design, Development and Therapy 2024, 18:1497-1498

Published Date: 2 May 2024

Review

Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs

Liu Y, Liang Y, Yuhong J, Xin P, Han JL, Du Y, Yu X, Zhu R, Zhang M, Chen W, Ma Y

Drug Design, Development and Therapy 2024, 18:1469-1495

Published Date: 1 May 2024

Clinical Trial Report

Dose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron

Sun XX, Qian J, Fan JM, Liu L, Jin XF, Xiao F

Drug Design, Development and Therapy 2024, 18:1459-1467

Published Date: 30 April 2024

Original Research

Integrated Network Pharmacology Analysis and Experimental Validation to Elucidate the Mechanism of Acteoside in Treating Diabetic Kidney Disease

Zhang SJ, Zhang YF, Bai XH, Zhou MQ, Zhang ZY, Zhang SX, Cao ZJ, Wang L, Ding SW, Zheng HJ, Liu YN, Yu GY, Liu WJ

Drug Design, Development and Therapy 2024, 18:1439-1457

Published Date: 30 April 2024

Original Research

Network and Experimental Pharmacology on Mechanism of Yixintai Regulates the TMAO/PKC/NF-κB Signaling Pathway in Treating Heart Failure

Wang Z, Liu C, Wei J, Yuan H, Shi M, Zhang F, Zeng Q, Huang A, Du L, Li Y, Guo Z

Drug Design, Development and Therapy 2024, 18:1415-1438

Published Date: 30 April 2024

Review

The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

Hu Q, Li Y, Lin Z, Zhang H, Chen H, Chao C, Zhao C

Drug Design, Development and Therapy 2024, 18:1399-1414

Published Date: 29 April 2024

Review

Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Zhang J, Wu L, Wang C, Xie X, Han Y

Drug Design, Development and Therapy 2024, 18:1385-1398

Published Date: 26 April 2024

Original Research

Dynasore Alleviates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis

Shan M, Wan H, Ran L, Ye J, Xie W, Lu J, Hu X, Deng S, Zhang W, Chen M, Wang F, Guo Z

Drug Design, Development and Therapy 2024, 18:1369-1384

Published Date: 23 April 2024

Original Research

Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis

Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H

Drug Design, Development and Therapy 2024, 18:1349-1368

Published Date: 23 April 2024

Original Research

Effect of Fluid Therapy in Early Morning on the Incidence of Post-Induction Hypotension During Non-Cardiac Surgery After Noon: A Single-Center Retrospective Study

Zhang Y, Wang X, Sang X, Zhou Z, Dai G, Zhang X

Drug Design, Development and Therapy 2024, 18:1339-1347

Published Date: 22 April 2024

Original Research

Validation of Core Ingredients and Molecular Mechanism of Cinobufotalin Injection Against Liver Cancer

Chen S, Li M, Xue C, Zhou X, Wei J, Zheng L, Duan Y, Deng H, Tang F, Xiong W, Xiang B, Zhou M

Drug Design, Development and Therapy 2024, 18:1321-1338

Published Date: 23 April 2024

Clinical Trial Report

The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude

Yang C, Dong W, Luo J, Ma M, Gao Y, Ni L, Liu H, Cha C, Xiao Y, Huang S

Drug Design, Development and Therapy 2024, 18:1313-1319

Published Date: 22 April 2024

Review

Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade

Vitamia C, Iftinan GN, Latarissa IR, Wilar G, Cahyanto A, Elamin KM, Wathoni N

Drug Design, Development and Therapy 2024, 18:1297-1312

Published Date: 22 April 2024

Review

RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models

Lin ZC, Hung CF, Aljuffali IA, Lin MH, Fang JY

Drug Design, Development and Therapy 2024, 18:1277-1296

Published Date: 23 April 2024

Original Research

Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway

Nan F, Tian Q, Chen S

Drug Design, Development and Therapy 2024, 18:1265-1275

Published Date: 18 April 2024

Retraction

Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways [Retraction]

Huang Y, Chen J, Yang S, Tan T, Wang N, Wang Y, Zhang L, Yang C, Huang H, Luo J, Luo X

Drug Design, Development and Therapy 2024, 18:1263-1264

Published Date: 18 April 2024

Original Research

Sinomenine Hydrochloride Protects IgA Nephropathy Through Regulating Cell Growth and Apoptosis of T and B Lymphocytes

Li JJ, Li L, Li S, Tang XY, Sun HF, Liu JX

Drug Design, Development and Therapy 2024, 18:1247-1262

Published Date: 17 April 2024

Original Research

Dexamethasone versus Dexmedetomidine as Adjuvants in Ultrasound Popliteal Sciatic Nerve Block for Hallux Valgus Surgery: A Mono-Centric Retrospective Comparative Study

Coviello A, Iacovazzo C, Cirillo D, Bernasconi A, Marra A, Squillacioti F, Martone M, Garone E, Coppola F, de Siena AU, Vargas M, Servillo G

Drug Design, Development and Therapy 2024, 18:1231-1245

Published Date: 17 April 2024

Review

Clinical Application and Research Progress of Remimazolam for Pediatric Patients

Bai C, Xu M, Guo Y, Jin Y, Zhao X

Drug Design, Development and Therapy 2024, 18:1221-1229

Published Date: 17 April 2024