Back to Archived Journals » Journal of Receptor, Ligand and Channel Research » Volume 2
Adenosine A2a receptor agonists as regulators of inflammation: pharmacology and therapeutic opportunities
Authors Morello S, Sorrentino R, Pinto A
Published 5 August 2009 Volume 2009:2 Pages 11—17
DOI https://doi.org/10.2147/JRLCR.S4710
Review by Single anonymous peer review
Peer reviewer comments 3
Silvana Morello, Rosalinda Sorrentino, Aldo Pinto
Department of Pharmaceutical Sciences, Biomedical Section, University of Salerno, Via Ponte don Melillo, 84084 Fisciano, Salerno, Italy
Abstract: A2a receptor (A2aR) plays an important role in the regulation of inflammatory and immune responses. The activation of PKA-dependent and/or -independent pathways are responsible for the downmodulation of inflammatory networks and tissue injury. Based on promising recent studies, selective A2aR agonists are under clinical investigations for a wide range of disorders, such as ischemia-reperfusion injury, chronic inflammation, and infectious diseases. Nevertheless, further studies are required to improve our understanding in the ability of A2a receptor agonists to reduce tissue damage during inflammation. Characterization of A2aR-induced signaling pathways will be useful for the development of novel therapeutic strategies in inflammatory/immune diseases.
Keywords: adenosine, A2a receptor, A2a receptor agonists, inflammation
© 2009 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.