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Journal of Receptor, Ligand and Channel Research ceased publishing in November 2018. All articles that have been published in Journal of Receptor, Ligand and Channel Research will continue to be available on the Dove Press site, and will be securely archived with CLOCKSS.
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Journal of Receptor, Ligand and Channel Research
ISSN: 1178-699X
- View all (46)
- Volume 10, 2018 (2)
- Volume 9, 2016 (1)
- Volume 8, 2015 (7)
- Volume 7, 2014 (8)
- Volume 6, 2013 (2)
- Volume 5, 2012 (2)
- Volume 4, 2011 (5)
- Volume 3, 2010 (12)
- Volume 2, 2009 (6)
- Volume 1, 2008 (1)
Journal Articles:
- 46 records -
![Noteworthy comment: There is rapidly growing interest in the Aryl Hydrocarbon Receptor (AHR) and its potential roles in acute and chronic disorders ranging from arthritis to various forms of cancer. In this paper Khazaal and colleagues propose, explore and support a new perspective on this receptor, linking it with circadian rhythmicity and, in turn, to significant disruption of basic metabolic processes. This view may introduce an even greater potential importance for the AHR by implicating it in the regulation of fundamental biology and an even greater number of pathologies for which it could represent a critical target for treatments](assets/img/article_icons/noteworthy.png)
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Environmental factors act through aryl hydrocarbon receptor activation and circadian rhythm disruption to regulate energy metabolism
Khazaal AQ, Jaeger CD, Bottum KM, Tischkau SA
Journal of Receptor, Ligand and Channel Research 2018, 10:13-24
Published Date: 25 May 2018
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Sialic acid receptors: focus on their role in influenza infection
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Ayora-Talavera G
Journal of Receptor, Ligand and Channel Research 2018, 10:1-11
Published Date: 10 April 2018
![Noteworthy comment: The Duffy chemokine receptor is involved in the infective process of the malaria parasite. It mediates the effect of the parasitic ligand, Duffy binding protein in permitting entry of the parasite into host blood cells. To date most attempts at therapeutic control via this interaction have focused on the binding protein, but this review covers the various approaches potentially available to target the receptor directly, providing a new promising strategy to treat malaria infection](assets/img/article_icons/noteworthy.png)
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The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects
Ntumngia FB, Thomson-Luque R, Pires CV, Adams JH,
Journal of Receptor, Ligand and Channel Research 2016, 9:1-11
Published Date: 26 September 2016
![Noteworthy comment: The search for effective but safe anti-depressant drugs continues in parallel with studies of dietary influences and the use of lifestyle factors such as exercise. In this short review Rodrigues and colleagues summarise key findings on these topics and draw together the evidence that they may act via a common pathway known as mTOR (mammalian Target Of Rapamycin). A more intensive investigation into this target could yield the more selective and useful drugs that are urgently needed](assets/img/article_icons/noteworthy.png)
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mTOR signaling in the neuropathophysiology of depression: current evidence
Réus GZ, Quevedo J, Rodrigues AL
Journal of Receptor, Ligand and Channel Research 2015, 8:65-74
Published Date: 23 November 2015
![Noteworthy comment: Voltage-gated ion channels are important factors in determining tissue excitability and are increasingly seen as potential targets for the treatment of new drugs in disorders such as epilepsy and cardiac dysfunction. This review focusses on the regulation of several varieties of voltage-gated channels, including sodium, potassium and chloride channels as well as related proteins, by the E3 ubiquitin ligase Nedd4-2. As such this is a novel and valuable summary and perspective of a rapidly growing field. It also serves to emphasise the potential therapeutic value of targeting new drugs on molecules that regulate channel function in addition to the channels themselves.](assets/img/article_icons/noteworthy.png)
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Nedd4-2 regulation of voltage-gated ion channels: an update on structure–function relationships and the pathophysiological consequences of dysfunction
Arévalo JC
Journal of Receptor, Ligand and Channel Research 2015, 8:53-63
Published Date: 18 August 2015
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mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel
Huang TQ, Zou MX, Pasek DA, Meissner G
Journal of Receptor, Ligand and Channel Research 2015, 8:43-51
Published Date: 20 May 2015
![Noteworthy comment: Despite the availability of several classes of drugs, migraine remains a difficult condition to treat effectively. This review provides an overview of three compounds : calcitonin gene related peptide (CGRP), brain natriuretic peptide (BNP) and ATP, whose intricate interactions contributes to the regulation of those neurons in the trigeminal system which generate the severe pain and other symptoms of migraine. Developing our knowledge of these compounds could lead to the generation of increasingly more effective drugs for the treatment of the condition.](assets/img/article_icons/noteworthy.png)
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Role of calcitonin gene-related peptide and brain natriuretic peptide to modulate the excitability state of trigeminal neurons: relevance to migraine pathology and treatment
Vilotti S, Fabbretti E, Nistri A
Journal of Receptor, Ligand and Channel Research 2015, 8:31-41
Published Date: 19 January 2015
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Phosphodiesterase inhibition in the treatment of autoimmune and inflammatory diseases: current status and potential
Miller MS
Journal of Receptor, Ligand and Channel Research 2015, 8:19-30
Published Date: 23 December 2014
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Pentameric viral ion channels: from structure to function
![](cr_data/cache/submission_images/s36000/36064/04_sep_2014_fig_5_model-01_200_200_90.jpg)
Surya W, Li Y, Torres J
Journal of Receptor, Ligand and Channel Research 2015, 8:9-18
Published Date: 22 December 2014
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Programmed death-1/programmed death-1 ligand axis as a therapeutic target in oncology: current insights
Schalper KA, Venur VA, Velcheti V
Journal of Receptor, Ligand and Channel Research 2015, 8:1-7
Published Date: 23 December 2014
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Pharmacophore modeling: advances, limitations, and current utility in drug discovery
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Qing XY, Lee XY, De Raeymaeker J, Tame JRH, Zhang KYJ, De Maeyer M, Voet ARD
Journal of Receptor, Ligand and Channel Research 2014, 7:81-92
Published Date: 11 November 2014
![Noteworthy Comment: The growth factor Brain-Derived Neurotrophic Factor (BDNF) has long been established as playing a crucial role in brain development, function and plasticity. This review covers many of these aspects and the role of BDNF in a range of disorders including schizophrenia, depression and inflammation-driven disorders of the CNS.](assets/img/article_icons/noteworthy.png)
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BDNF–TrkB signaling as a therapeutic target in neuropsychiatric disorders
Du X, Wu YC, Hill RA
Journal of Receptor, Ligand and Channel Research 2014, 7:61-79
Published Date: 6 October 2014
![Noteworthy Comment: Potassium channels are being increasingly recognised as critical contributors to the physiological regulation of tissue function and to several major disorders. They have for many years been the target for drugs in the treatment of some conditions such as hypertension. This review provides a concise but timely and focussed review of the role of potassium channels specifically in the control of vascular tone and should stimulate further work and new drug development in this area](assets/img/article_icons/noteworthy.png)
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K+ channels in biological processes: vascular K+ channels in the regulation of blood pressure
Werner ME, Ledoux J
Journal of Receptor, Ligand and Channel Research 2014, 7:51-60
Published Date: 30 September 2014
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The AMPA receptor as a therapeutic target in epilepsy: preclinical and clinical evidence
Hanada T
Journal of Receptor, Ligand and Channel Research 2014, 7:39-50
Published Date: 18 September 2014
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Structure-based three-dimensional pharmacophores as an alternative to traditional methodologies
Gaurav A, Gautam V
Journal of Receptor, Ligand and Channel Research 2014, 7:27-38
Published Date: 12 June 2014
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Adipokines: biological functions and metabolically healthy obese profile
Pereira SS, Alvarez-Leite JI
Journal of Receptor, Ligand and Channel Research 2014, 7:15-25
Published Date: 15 May 2014
![Noteworthy Comment: The large conductance calcium and voltage-gated potassium channels (BK-Ca) are present in most tissues and regulate a wide range of physiological functions. This review summarises the structure, molecular interactions and functional roles of these crucial channels as well as their potential involvement in disease states.](assets/img/article_icons/noteworthy.png)
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BKCa channels as physiological regulators: a focused review
Vetri F, Choudhury MSR, Pelligrino DA, Sundivakkam P
Journal of Receptor, Ligand and Channel Research 2014, 7:3-13
Published Date: 31 March 2014
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Interaction of recombinant and native Cav2.3 E-/R-type voltage-gated Ca2+ channels with the molecular chaperone Hsp70 [Corrigendum]
Radhakrishnan K, Krieger A, Tevoufouet EE, Dietz GP, Nagel F, Bähr M, Hescheler J, Schneider T
Journal of Receptor, Ligand and Channel Research 2014, 7:1-2
Published Date: 17 January 2014
![Noteworthy Comment: Orphan nuclear receptors are involved in a wide range of cellular developmental and functional activities, many of which are regulated at the genetic level. As a result they are fundamental to normal cellular processes and their abnormalities in a variety of disease states. This article brings together a significant amount of published information into a valuable and timely review.](assets/img/article_icons/noteworthy.png)
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Orphan nuclear receptors: current perspectives
Ranhotra HS
Journal of Receptor, Ligand and Channel Research 2013, 6:15-25
Published Date: 7 November 2013
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Myocardial calcium signaling in physiology and disease
Kang S, Lebeche D
Journal of Receptor, Ligand and Channel Research 2013, 6:1-13
Published Date: 16 September 2013
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Alcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors
Gallois-Bernos AC, Thurmond RL
Journal of Receptor, Ligand and Channel Research 2012, 5:9-20
Published Date: 20 December 2012
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Liposome mitigation of curcumin inhibition of cardiac potassium delayed-rectifier current
Helson L, Shopp G, Bouchard A, Majeed M
Journal of Receptor, Ligand and Channel Research 2012, 5:1-8
Published Date: 16 November 2012
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Specific mechanism of action of amisulpride in the treatment of schizophrenia and correlation with clinical response and tolerability
Juruena MF, de Sena EP, de Oliveira IR
Journal of Receptor, Ligand and Channel Research 2011, 4:49-55
Published Date: 26 August 2011
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An in silico approach to primaquine binding to Trp756 in the external vestibule of sodium channel Nav 1.4
Scior TF, Islas AA, Martínez-Morales E, Cuanalo-Contreras K, Millan-Perezpeña L, Salinas-Stefanón EM
Journal of Receptor, Ligand and Channel Research 2011, 4:41-48
Published Date: 26 July 2011
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Interaction of recombinant and native Cav2.3 E-/R-type voltage-gated Ca2+ channels with the molecular chaperone Hsp70
Radhakrishnan K, Krieger A, Tevoufouet EE, Dietz GP, Nagel F, Bähr M, Hescheler J, Schneider T
Journal of Receptor, Ligand and Channel Research 2011, 4:29-40
Published Date: 23 June 2011
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Clinical response and tolerability of eslicarbazepine in treatment of partial onset seizures: impact of a novel metabolic pathway
Serrano E, Harden C
Journal of Receptor, Ligand and Channel Research 2011, 4:23-28
Published Date: 20 April 2011
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Glutamate pathway implication in amyotrophic lateral sclerosis: what is the signal in the noise?
Virginia Le Verche, Burcin Ikiz, Arnaud Jacquier, et al
Journal of Receptor, Ligand and Channel Research 2011, 4:1-22
Published Date: 22 December 2010
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Hydrophobicity profiles in G protein-coupled receptor transmembrane helical domains
Chiquito J Crasto
Journal of Receptor, Ligand and Channel Research 2010, 3:123-133
Published Date: 1 December 2010
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Dual receptor blockade by bosentan: clinical experience in treatment of pulmonary hypertension
Susana Hoette, Dermot S O’Callaghan, Carlos Jardim, et al
Journal of Receptor, Ligand and Channel Research 2010, 3:113-121
Published Date: 23 November 2010
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Incretins and the specific mechanism of action of liraglutide, the first applicable human glucagon-like peptide 1 analog in the treatment of type 2 diabetes
Edoardo Mannucci, Caterina Lamanna
Journal of Receptor, Ligand and Channel Research 2010, 3:105-112
Published Date: 23 September 2010
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Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo
Tomohiro Chiba, Marina Yamada, Kosuke Torii, et al
Journal of Receptor, Ligand and Channel Research 2010, 3:97-104
Published Date: 12 August 2010
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Modularity in receptor evolution: insulin- and glucagon-like peptide modules as binding sites for insulin and glucose in the insulin receptor
Robert Root-Bernstein, Jessica Vonck
Journal of Receptor, Ligand and Channel Research 2010, 3:87-96
Published Date: 26 July 2010
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Ligand competition assays indicate allosterism and insufficiency of the ternary complex model
Eyad Qunaibi, Roger Barber
Journal of Receptor, Ligand and Channel Research 2010, 3:73-86
Published Date: 14 July 2010
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Creatine supplementation upregulates excitation-contraction coupling in C2C12 myotubes
Aida Calderón-Rivera, Ana Victoria Vega, Guillermo Avila
Journal of Receptor, Ligand and Channel Research 2010, 3:63-71
Published Date: 26 May 2010
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Tachykinins and neurokinin receptors in bone marrow functions: neural-hematopoietic link
Tilman E Klassert, Shyam A Patel, Pranela Rameshwar
Journal of Receptor, Ligand and Channel Research 2010, 3:51-61
Published Date: 29 April 2010
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Pharmacological characterization of oxime agonists of the histamine H4 receptor
Fuqu Yu, Ronald L Wolin, Jianmei Wei, et al
Journal of Receptor, Ligand and Channel Research 2010, 3:37-49
Published Date: 16 December 2009
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The role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases
Masatomo Ishikawa, Kenji Hashimoto
Journal of Receptor, Ligand and Channel Research 2010, 3:25-36
Published Date: 16 December 2009
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Dominant negative effect of the extracellular domain of CASR
Min Pi, Junhui Chen, Wenyu Zhu, et al
Journal of Receptor, Ligand and Channel Research 2010, 3:15-23
Published Date: 16 December 2009
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Overview of the LDL receptor: relevance to cholesterol metabolism and future approaches for the treatment of coronary heart disease
William R Lagor, John S Millar
Journal of Receptor, Ligand and Channel Research 2010, 3:1-14
Published Date: 17 December 2009
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NMDA-gated ion channel research and its therapeutic potentials in neurodegenerative diseases: a review
Maryam Majdi, Huei-Sheng Vincent Chen
Journal of Receptor, Ligand and Channel Research 2009, 2:59-73
Published Date: 25 November 2009
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Autoantibodies, human Fcγ receptors, and autoimmunity
Margherita Sisto, Sabrina Lisi, Simona D’Amore, et al
Journal of Receptor, Ligand and Channel Research 2009, 2:45-57
Published Date: 4 November 2009
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GIRK2 and neuronal pattern of generation and settling in homozygous weaver mice
Joaquín Martí, María C Santa-Cruz, Shirley A Bayer, José P Hervás
Journal of Receptor, Ligand and Channel Research 2009, 2:29-44
Published Date: 12 October 2009
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Nucleic acid recognizing Toll-like receptors as therapeutic targets: a focus on autoimmunity and cancer
Philipp Yu
Journal of Receptor, Ligand and Channel Research 2009, 2:19-28
Published Date: 31 August 2009
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Adenosine A2a receptor agonists as regulators of inflammation: pharmacology and therapeutic opportunities
Silvana Morello, Rosalinda Sorrentino, Aldo Pinto
Journal of Receptor, Ligand and Channel Research 2009, 2:11-17
Published Date: 5 August 2009
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In silico modeling of toluene binding site in the pore of voltage-gate sodium channel
Thomas RF Scior, Evelyn Martínez-Morales, Silvia L Cruz, Eduardo M Salinas-Stefanon
Journal of Receptor, Ligand and Channel Research 2009, 2:1-2
Published Date: 13 January 2009
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ATP8A1 activity and phosphatidylserine transbilayer movement
Eric Soupene, Dwi Utami Kemaladewi, Frans A Kuypers
Journal of Receptor, Ligand and Channel Research 2008, 1:1-10
Published Date: 22 September 2008