Abdelrahaman D, Habotta OA, Ateya A, Aldarmahi AA, El-Shafei RA, Badawy MM, El-Mansy AA, A-Elgadir TM, Nada AM, Elhadidy MG, Hamza E, Alwutayed KM, El-Sherbiny M, Fericean L, Imbrea F, Abdeen A

Drug Design, Development and Therapy 2024, 18:2989-3004

Published Date: 16 July 2024

Original Research

Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses

Li F, Jia Y, Fang J, Gong L, Zhang Y, Wei S, Wu L, Jiang P

Drug Design, Development and Therapy 2024, 18:2971-2987

Published Date: 15 July 2024

Original Research

Tangzhiping Decoction Improves Glucose and Lipid Metabolism and Exerts Protective Effects Against White Adipose Tissue Dysfunction in Prediabetic Mice

Wang C, An T, Lu C, Liu T, Shan X, Zhu Z, Gao Y

Drug Design, Development and Therapy 2024, 18:2951-2969

Published Date: 15 July 2024

Review

Nanoparticle-Based Drug Delivery Systems for Inflammatory Bowel Disease Treatment

Gao J, Li J, Luo Z, Wang H, Ma Z

Drug Design, Development and Therapy 2024, 18:2921-2949

Published Date: 15 July 2024

Letter

Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery [Letter]

Satici MH, Altay N

Drug Design, Development and Therapy 2024, 18:2919-2920

Published Date: 11 July 2024

Original Research

Oral Bioavailability, Tissue Distribution, Metabolism, and Excretion of Panduratin A from Boesenbergia rotunda Extract in Healthy Rats

Kongratanapasert T, Boonyarattanasoonthorn T, Supannapan K, Hongeng S, Khemawoot P

Drug Design, Development and Therapy 2024, 18:2905-2917

Published Date: 11 July 2024

Clinical Trial Report

Pharmacokinetics and Safety of Estradiol Valerate Tablet and Its Generic: A Phase 1 Bioequivalence Study in Healthy Chinese Postmenopausal Female Subjects

Zhang L, Li M, Fan L, Liu F, Zhang P, Huang Q, Mai G, Shentu J

Drug Design, Development and Therapy 2024, 18:2891-2904

Published Date: 10 July 2024

Clinical Trial Report

The Influence of Piriform Recess Instillation with Lidocaine Before Bronchoscopy on Post-General Anesthesia Cough: A Randomized Controlled Trial

Min K, Wang Y, Feng D, Jin T, Zhu W, Duan R, Lv X

Drug Design, Development and Therapy 2024, 18:2883-2890

Published Date: 9 July 2024

Original Research

Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson’s Disease

Cai B, Wang Q, Zhong L, Liu F, Wang X, Chen T

Drug Design, Development and Therapy 2024, 18:2869-2881

Published Date: 9 July 2024

Original Research

Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-κB/HIF-1α Pathway by Bioinformatics and Experimental Validation

Li J, Dan W, Zhang C, Liu N, Wang Y, Liu J, Zhang S

Drug Design, Development and Therapy 2024, 18:2847-2868

Published Date: 9 July 2024

Clinical Trial Report

Nalbuphine in Pediatric Emergence Agitation Following Cochlear Implantation: A Randomized Trial

Li Y, Li Q, Zhao G, Zhang H, Zhong H, Zeng Y

Drug Design, Development and Therapy 2024, 18:2837-2845

Published Date: 8 July 2024

Original Research

The Efficacy of Letrozole Co-Treatment in an Antagonist Protocol for Women with Polycystic Ovary Syndrome Undergoing IVF: A Retrospective Study

Lin J, Wu F, Zhu Y, Zhu Q, Du T, Lin J

Drug Design, Development and Therapy 2024, 18:2823-2835

Published Date: 8 July 2024

Clinical Trial Report

Determination of ED90s of Phenylephrine and Norepinephrine Infusion for Prevention of Spinal Anesthesia-Induced Hypotension in Patients with Preeclampsia During Cesarean Delivery

Tan H, Chen Y, Jiang Y, Sun X, Ye W, Zhu X, Xiong X

Drug Design, Development and Therapy 2024, 18:2813-2821

Published Date: 5 July 2024

Original Research

Inflammation Can Be a High-Risk Factor for Mucosal Nonunion of MRONJ by Regulating SIRT1 Signaling When Treated with an Oncologic Dose of Zoledronate

Zhu S, Cui Y, Zhang W, Ji Y, Li L, Luo S, Cui J, Li M

Drug Design, Development and Therapy 2024, 18:2793-2812

Published Date: 4 July 2024

Original Research

Thymopentapeptide Affects T-Cell Subsets by Modulating the Flora of the Skin Surface to Alleviate Psoriasis

Liu X, Xi R, Du X, Wang Y, Cheng L, Yan G, Lu H, Liu T, Li F

Drug Design, Development and Therapy 2024, 18:2775-2791

Published Date: 4 July 2024

Original Research

Clinical Efficacy of Taxol Plus Platinum (TP) Chemotherapy Combined with Delayed Administration of PD-1 Inhibitors in Patients with Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Study

Shen L, Chen Z, Zhang Z, Wu Y, Ren Y, Li Y, Li Y, Yin X, Han F, Chen Y

Drug Design, Development and Therapy 2024, 18:2761-2773

Published Date: 3 July 2024

Original Research

Schisandra chinensis Bee Pollen Extract Inhibits Proliferation and Migration of Hepatocellular Carcinoma HepG2 Cells via Ferroptosis-, Wnt-, and Focal Adhesion–Signaling Pathways

Li Z, Yang J, Sun Y, Han S, Gong J, Zhang Y, Feng Z, Yao H, Shi P

Drug Design, Development and Therapy 2024, 18:2745-2760

Published Date: 2 July 2024

Original Research

Pharmacokinetics and Safety of Oliceridine Fumarate Injection in Chinese Patients with Chronic Non-Cancer Pain: A Phase I, Single-Ascending-Dose, Open-Label Clinical Trial

Ni Y, Huang R, Yang S, Yang XY, Zeng S, Yao A, Huang J, Yang G

Drug Design, Development and Therapy 2024, 18:2729-2743

Published Date: 3 July 2024

Review

Advances in Research on the Effectiveness and Mechanism of Active Ingredients from Traditional Chinese Medicine in Regulating Hepatic Stellate Cells Autophagy Against Hepatic Fibrosis

Liu XY, Zhang W, Ma BF, Sun MM, Shang QH

Drug Design, Development and Therapy 2024, 18:2715-2727

Published Date: 2 July 2024

Retraction

4-Amino-2-Trifluoromethyl-Phenyl Retinate Inhibits Proliferation, Invasion, and Migration of Breast Cancer Cells by Independently Regulating CRABP2 and FABP5 [Retraction]

Ju J, Wang N, Wang J, Wu F, Ge J, Chen F

Drug Design, Development and Therapy 2024, 18:2713-2714

Published Date: 3 July 2024

Original Research

Costunolide Inhibits Chronic Kidney Disease Development by Attenuating IKKβ/NF-κB Pathway

Zhao Y, Wang YH, Tu WC, Wang DW, Lu MJ, Shao Y

Drug Design, Development and Therapy 2024, 18:2693-2712

Published Date: 2 July 2024

Original Research

Etomidate Combined with Propofol versus Remimazolam for Sedation in Elderly Patients During Gastrointestinal Endoscopy: A Randomized Prospective Clinical Trial

Zhang Q, Zhao R, Wu Y, Zhang L, Feng Y

Drug Design, Development and Therapy 2024, 18:2681-2692

Published Date: 2 July 2024

Original Research

Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53

Klett T, Schwer M, Ernst LN, Engelhardt MU, Jaag SJ, Masberg B, Knappe C, Lämmerhofer M, Gehringer M, Boeckler FM

Drug Design, Development and Therapy 2024, 18:2653-2679

Published Date: 1 July 2024

Original Research

Pharmacokinetic Interactions Between the Fixed-Dose Combination of Ezetimibe/Rosuvastatin 10/20 Mg and the Fixed-Dose Combination of Telmisartan/Amlodipine 80/5 Mg in Healthy Subjects

Ryu H, Kim HC, Jeon I, Jang IJ, Cho JY, Kim KT, Oh J

Drug Design, Development and Therapy 2024, 18:2641-2652

Published Date: 1 July 2024

Original Research

Integration of Gut Microbiota, Serum Metabolomic, and Network Pharmacology to Reveal the Anti Insomnia Mechanism of Mongolian Medicine Sugemule-4 Decoction on Insomnia Model Rats

Du L, Yang D, Wu L, Mei L, Wu S, Ba Y, Bao Y, Su R, Song L

Drug Design, Development and Therapy 2024, 18:2617-2639

Published Date: 27 June 2024

Clinical Trial Report

Up-and-Down Determination of Different Crystalloid Coload Volumes on the ED 90 of Prophylactic Norepinephrine Infusion for Preventing Postspinal Anesthesia Hypotension During Cesarean Section

Chen Y, Xiong X, Qin R, Guo L, Shi Y, Ni X

Drug Design, Development and Therapy 2024, 18:2609-2616

Published Date: 26 June 2024

Original Research

A Health Technology Assessment Based on Chinese Guideline: Active Vitamin D and Its Analogs in the Treatment of Osteoporosis

Huang S, Li J, Hu X, Chen J

Drug Design, Development and Therapy 2024, 18:2593-2608

Published Date: 26 June 2024

Original Research

A Visual Analysis of the Research Dynamics in Resistance to EGFR Inhibitors for NSCLC

Shao J, Gu Y, Guo R, Xu J

Drug Design, Development and Therapy 2024, 18:2571-2591

Published Date: 26 June 2024

Review

Clinical Pharmacokinetics of Semaglutide: A Systematic Review

Yang XD, Yang YY

Drug Design, Development and Therapy 2024, 18:2555-2570

Published Date: 25 June 2024

Review

Anti-Infection of Oral Microorganisms from Herbal Medicine of Piper crocatum Ruiz & Pav

Kurnia D, Lestari S, Mayanti T, Gartika M, Nurdin D

Drug Design, Development and Therapy 2024, 18:2531-2553

Published Date: 25 June 2024

Review

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Luo Y, Bai XY, Zhang L, Hu QQ, Zhang N, Cheng JZ, Hou MZ, Liu XL

Drug Design, Development and Therapy 2024, 18:2485-2529

Published Date: 21 June 2024

Clinical Trial Report

Comparison of Ciprofol-Based and Propofol-Based Total Intravenous Anesthesia on Microvascular Decompression of Facial Nerve with Neurophysiological Monitoring: A Randomized Non-Inferiority Trial

Zhu T, Kang F, Han MM, He F, Jiang S, Hao LN, Huang X, Li J

Drug Design, Development and Therapy 2024, 18:2475-2484

Published Date: 21 June 2024

Original Research

Short–Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice

Sun L, Bing H, Zhang C, Lin L, Lian H, Chu Q, Jin X

Drug Design, Development and Therapy 2024, 18:2461-2474

Published Date: 20 June 2024

Review

Targeting WEE1 Kinase in Gynecological Malignancies

Zhang W, Li Q, Yin R

Drug Design, Development and Therapy 2024, 18:2449-2460

Published Date: 20 June 2024

Original Research

Investigating the Impact of SN-38 on Mouse Brain Metabolism Based on Metabolomics

Zhu X, Huang Y, Ding J, Liu J, Cui C, Han G

Drug Design, Development and Therapy 2024, 18:2435-2447

Published Date: 20 June 2024

Original Research

Xinfeng Capsule Inhibits Pyroptosis and Ameliorates Myocardial Injury in Rats with Adjuvant Arthritis via the GAS5/miR-21/TLR4 Axis

Fu W, Cao Y, Liu J, Huang C, Shu K, Zhu N

Drug Design, Development and Therapy 2024, 18:2421-2433

Published Date: 20 June 2024

Original Research

Exploration of the Active Component and Mechanisms of Shengyu Decoction Against Myelosuppression Using Network Pharmacology and in vitro Experimental Validation

Ma B, Hou P, Liu R, Cang A, Zhao L

Drug Design, Development and Therapy 2024, 18:2405-2420

Published Date: 20 June 2024

Retraction

5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3 [Retraction]

Yu Z, Chan S, Wang X, Sun R, Wang M, Wang Z, Zuo X, Chen J, Zhang H, Chen W

Drug Design, Development and Therapy 2024, 18:2403-2404

Published Date: 19 June 2024

Original Research

Intravenous Bolus of Dexmedetomidine for Treatment of Severe Shivering After Caesarean Delivery Under Combined Spinal-Epidural Anaesthesia: A Randomized Dose-Response Study

Yang M, Li S, Drzymalski D, Chen X

Drug Design, Development and Therapy 2024, 18:2393-2402

Published Date: 19 June 2024

Original Research

Esketamine Combined with Dexmedetomidine to reduce Visceral Pain During elective Cesarean Section Under Combined Spinal-Epidural Anesthesia: A double-Blind Randomized Controlled Study

Yang JR, Li YY, Ran TJ, Lin XY, Xu JY, Zhou SL, Huang PJ

Drug Design, Development and Therapy 2024, 18:2381-2392

Published Date: 18 June 2024

Original Research

4-Deoxy-ϵ-Pyrromycinone: A Promising Drug/Lead Compound to Treat Tumors

Zhang J, Sang X, Yuan Y, Shen J, Fang Y, Qin M, Zheng H, Zhu Z

Drug Design, Development and Therapy 2024, 18:2367-2379

Published Date: 18 June 2024

Original Research

Determining the Maximum Tolerable Concentration of Ropivacaine to Maintain Sensation of the Nerve Root in Percutaneous Endoscopic Transforaminal Lumbar Discectomy: Can Epidural Anaesthesia Achieve Pain-Tactile Separation Block to Avoid Nerve Injury?

Hu B, Kang X, Zhou C, Zhou J, Xu W, Ding W, Feng Z, Wang H

Drug Design, Development and Therapy 2024, 18:2357-2366

Published Date: 18 June 2024

Clinical Trial Report

ED50 and ED95 of Remimazolam Tosilate Combined with Different Doses of Fentanyl in Elderly Patients for Painless Gastroscopy

Guo Y, Yao Z, Feng Y, Wang D, Wang Y, Lin J

Drug Design, Development and Therapy 2024, 18:2347-2356

Published Date: 18 June 2024

Review

The Role and Therapeutic Potential of Melatonin in Degenerative Fundus Diseases: Diabetes Retinopathy and Age-Related Macular Degeneration

Ma C, Li H, Lu S, Li X

Drug Design, Development and Therapy 2024, 18:2329-2346

Published Date: 18 June 2024

Original Research

Comparison of the Safety and Efficacy of Remimazolam Besylate versus Dexmedetomidine for Patients Undergoing Fiberoptic Bronchoscopy: A Prospective, Randomized Controlled Trial

Xu H, Wang L, Zhu W, Ren C, Liu G, Liu Y

Drug Design, Development and Therapy 2024, 18:2317-2327

Published Date: 18 June 2024