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Therapeutics and Clinical Risk Management
Open access peer-reviewed scientific and medical journals.
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Therapeutics and Clinical Risk Management
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Editor in Chief Professor Garry Walsh
In-hospital resuscitation: opioids and other factors influencing survivalKaramarie Fecho, Freeman Jackson, Frances Smith, et al
Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol
Eric A Harris, David A Lubarsky, Keith A Candiotti
Update on the management of attention-deficit/hyperactivity disorder in children and adults: patient onsiderations and the role of lisdexamfetamine
Brian J Cowles
An evidence-based review of natalizumab therapy in the management of Crohn’s disease
Raja GR Edula, Michael F Picco
Exercise-induced bronchoconstriction: The effects of montelukast, a leukotriene receptor antagonist
James P Kemp
The pathophysiology of paroxysmal nocturnal hemoglobinuria and treatment with eculizumab
Richard Kelly, Stephen Richards, Peter Hillmen, et al
Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability
Andre R Brunoni, Renerio Fraguas Jr, Felipe Fregni
Celecoxib in arthritis: relative risk management profile and implications for patients
Gayle McKellar, Gurkirpal Singh
Fesoterodine for the treatment of urinary incontinence and overactive bladder
Pamela Ellsworth
New therapies in the management of Niemann-Pick type C disease: clinical utility of miglustat
James E Wraith, Jackie Imrie
Update on the use of deferasirox in the management of iron overload
Ali Taher, Maria Domenica Cappellini
The role of rifaximin in the treatment and chemoprophylaxis of travelers' diarrhea
Hoonmo L Koo, Herbert L DuPont, David B Huang
Pediatric psoriasis: an update
Nanette B Silverberg
Antimicrobial prophylaxis in colorectal surgery: focus on ertapenem
Fausto de Lalla
Lasofoxifene for the prevention and treatment of postmenopausal osteoporosis
E Michael Lewiecki
Artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria
Stephan Ehrhardt, Christian G Meyer
The role of urate and xanthine oxidase in vascular oxidative stress: future directions
Jacob George, Allan Struthers
Safety and efficacy of telbivudine for the treatment of chronic hepatitis B
Melissa K Osborn
Five-year alendronate treatment outcome in older postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures
Jun Iwamoto, Atsushi Miyata, Yoshihiro Sato, et al
Pemetrexed as first-line therapy for non-squamous non-small cell lung cancer
Serena Ricciardi, Silverio Tomao, Filippo de Marinis
Alglucosidase alfa: Long term use in the treatment of patients with Pompe disease
Michael Beck
Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety
Christoph Kellinghaus
Role of hydroxycarbamide in prevention of complications in patients with sickle cell disease
NM Wiles, J Howard
Dyslipidemia in Iranian overweight and obese children
Robabeh Ghergerehchi
Anticholinergic syndrome following an unintentional overdose of scopolamine
Carmela E Corallo, Ann Whitfield, Adeline Wu
Long-term efficacy and safety of letrozole for the adjuvant treatment of early breast cancer in postmenopausal women: a review
Alain Monnier
Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
S Deandrea, O Corli, I Moschetti, et al
Role of everolimus in the treatment of renal cell carcinoma
Saby George, Ronald M Bukowski
Incretin-based therapies: new treatments for type 2 diabetes in the new millennium
Joan Khoo, Christopher K Rayner, Karen L Jones, et al
Comparison of linear–stochastic and nonlinear–deterministic algorithms in the analysis of 15-minute clinical ECGs to predict risk of arrhythmic death
James E Skinner, Michael Meyer, Brian A Nester, et al
Prophylatic treatment of migraine and migraine clinical variants with topiramate: an update
Sergio Carmona, Osvaldo Bruera
Managing pediatric hepatitis C: current and emerging treatment options
Wikrom Karnsakul, Mary Kay Alford, Kathleen B Schwarz
Pegylated liposomal doxorubicin in ovarian cancer
Robert Strother, Daniela Matei
Epileptic seizure after treatment with thiocolchicoside
Pedro Giavina-Bianchi, Mara Giavina-Bianchi, Luciana Kase Tanno, et al
Parenteral clevidipine for the acute control of blood pressure in the critically ill patient: a review
W Frank Peacock IV, Jorge E Angeles, Karina M Soto, et al
Current trends in the treatment of hepatic encephalopathy
Mohamad Rasm Al Sibae, Brendan M McGuire
Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir
Michael Neely, Andrea Kovacs
Natalizumab in the treatment of multiple sclerosis
Brandon A Brown
Management strategies for pulmonary sarcoidosis
Robina Kate Coker
The levonorgestrel-releasing intrauterine system: Safety, efficacy, and patient acceptability
Megan N Beatty, Paul D Blumenthal
Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency
Danilo Fintini, Claudia Brufani, Marco Cappa
A comparative study of the prevalence of hyperkalemia with the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers
Seyed Ali Sadjadi, James I McMillan, Navin Jaipaul, Patricia Blakely, et al.
Does nonadherence to local recommendations for empirical antibiotic therapy on admission to the intensive care unit have an impact on in-hospital mortality?
Jean-Luc Baudel, Jacques Tankovic, Fabrice Carrat, Cécile Vigneau, et al.
Finasteride in the treatment of patients with benign prostatic hyperplasia: a review
Angela B Smith, Culley C Carson
Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain
Howard S Smith, Timothy R Deer
Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis
Devi Mukkai Krishnamurty, Atoosa Rabiee, Sanjay B Jagannath, Dana K Andersen
Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis
Jun Iwamoto, Mitsuyoshi Uzawa, Yoshihiro Sato, Tsuyoshi Takeda, et al.
EUS-guided transmural drainage for peripancreatic fluid collections using fine needle and stiff fine guidewire without electrocautery: An optional safe technique
Hiroyuki Miyatani, Yukio Yoshida
Guidelines for the treatment of bacterial vaginosis: focus on tinidazole
Laura J Dickey, Michael D Nailor, Jack D Sobel
Substitution of anticonvulsant drugs
Bernhard J Steinhoff, Uwe Runge, Otto W Witte, Hermann Stefan, et al.
Pharmacotherapy of pediatric and adolescent HIV infection
Susan J Schuval
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
Eduardo Pimenta, Suzanne Oparil
Treatment of recurrent epithelial ovarian cancer
Carmela Pisano, Giovanni S Bruni, Gaetano Facchini, Claudia Marchetti, et al.
The benefits and risks of testosterone replacement therapy: a review
Nazem Bassil, Saad Alkaade, John E Morley
Luteal phase support in assisted reproductive technology treatment: focus on Endometrin® (progesterone) vaginal insert
Jerome H Check
Role of rasagiline in treating Parkinson’s disease: effect on disease progression
Irene A Malaty, Hubert H Fernandez
Minimizing cardiac surgery risks in a Hepatitis C patient: Changing surgical strategy after evaluation by modern imaging technologies
Felix Kur, Andres Beiras-Fernandez, Martin Oberhoffer, Konstantin Nikolaou, et al.
Recombinant factor VIII in the management of hemophilia A: current use and future promise
Jerry S Powell
Managing Behçet’s disease: An update on current and emerging treatment options
P LA van Daele, J H Kappen, P M van Hagen, J AM van Laar
Casopitant: a novel NK1-receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting
Christina Ruhlmann, Jørn Herrstedt
Once-daily medications for the pharmacological management of ADHD in adults
Oleg v Tcheremissine, Lori M Lieving
Current trends in the treatment of polycystic ovary syndrome with desire for children
Margalida E Sastre, Maria O Prat, Miguel Angel Checa, Ramon C Carreras
Fatty liver in children
Mandana Rafeey, Fakhrossadat Mortazavi, Nafiseh Mogaddasi, Ghergherehchi Robabeh, et al.
Anthracycline extravasation injuries: management with dexrazoxane
Karin Jordan, Timo Behlendorf, Franziska Mueller, Hans-Joachim Schmoll
Mycophenolic acid formulations in adult renal transplantation – update on efficacy and tolerability
Déla Golshayan, M Pascual, Bruno Vogt
Emerging role of integrase inhibitors in the management of treatment-experienced patients with HIV infection
Christine Katlama, Robert Murphy
Antimalarials and the fight against malaria in Brazil
Luiz MA Carmargo, Saulo de Oliveira, Sergio Basano, Célia RS Garcia
Associations of anemia persistency with medical expenditures in Medicare ESRD patients on dialysis
Jiannong Liu, Haifeng Guo, David Gilbertson, Robert Foley, et al.
Management of glucocorticoids-induced osteoporosis: role of teriparatide
Silvia Migliaccio, Marina Brama, Nazzarena Malavolta
Cecal perforation with an ascending colon cancer caused by upper gastrointestinal endoscopy
Hiroyuki Miyatani, Yukio Yoshida, Hirokazu Kiyozaki
Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women
Sharath Gangadhara, Gianfilippo Bertelli
Dasatinib in chronic myeloid leukemia: a review
Dolly G Aguilera, Apostolia M Tsimberidou
Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamide
Russell P Saneto, Gail D Anderson
Recombinant human epoetin beta in the treatment of chemotherapy-related anemia
Iain RJ Macpherson, Colin R Lindsay, Nicholas S Reed
Animal-derived surfactants for the treatment and prevention of neonatal respiratory distress syndrome: summary of clinical trials
J Wells Logan, Fernando R Moya
Incidence and causes of neonatal hyperbilirubinemia in a center of Catania
Marco Sciuto, Gaetano Bertino, Mariangela Zocco, Ignazio Vecchio, et al.
Development of mucosal adjuvants for intranasal vaccine for H5N1 influenza viruses
Hideki Hasegawa, Takeshi Ichinohe, Akira Ainai, Shin-ichi Tamura, Takeshi Kurata
Fludarabine in the treatment of chronic lymphocytic leukemia: a review
Francesca Ricci, Alessandra Tedeschi, Enrica Morra, Marco Montillo
Role of oxaliplatin in the treatment of colorectal cancer
Pasquale Comella, Rossana Casaretti, Claudia Sandomenico, Antonio Avallone, Luca Franco
Challenging issues in molecular-targeted therapy
Zoheir Ezziane
Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations
Alberto Borgioli, Christian Viviani, Marco Duvina, Leila Brancato, Giuseppe Spinelli, et al
Regimen complexity and medication nonadherence in elderly patients
Andrea Corsonello, Claudio Pedone, Fabrizia Lattanzio, Maria Lucchetti, Sabrina Garasto, et al.
Intraperitoneal chemotherapy in the management of ovarian cancer: focus on carboplatin
Maurie Markman
Tenofovir and its potential in the treatment of hepatitis B virus
Laura Reynaud, Maria Aurora Carleo, Maria Talamo, Guglielmo Borgia
Treatment of osteoporosis with annual iv zoledronic acid: effects on hip fracture
Roland D Chapurlat
Role of combination bortezomib and pegylated liposomal doxorubicin in the management of relapsed and/or refractory multiple myeloma
Jatin J Shah, Robert Z Orlowski, Sheeba K Thomas
Mycophenolate mofetil: safety and efficacy in the prophylaxis of acute kidney transplantation rejection
Pranav Dalal, Monica Grafals, Darshika Chhabra, Lorenzo Gallon
Nd: YAG capsulotomy for posterior capsule opacification after combined clear corneal phacoemulsification and vitrectomy
Ilias Georgalas, Petros Petrou, George Kalantzis, Dimitrios Papaconstantinou, Chrysanthi Koutsandrea, Ioannis Ladas
Role of atazanavir in the treatment of HIV infection
Pablo Rivas, Judit Morello, Carolina Garrido, Sonia Rodríguez-Nóvoa, Vincent Soriano
A controlled, randomized nonblinded clinical trial to assess the efficacy of amphotericin B deoxycholate as compared to pentamidine for the treatment of antimony unresponsive visceral leishmaniasis cases in Bihar, India
Vidya Nand Rabi Das, Niyamat Ali Siddiqui, Krishna Pandey, Vijay Pratap Singh, Roshan K Topno, et al
A review of the use of exemestane in early breast cancer
Andrew Robinson
A new extended release formulation (OROS®) of hydromorphone in the management of pain
Sharon M Weinstein
Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety
Helen Y How, Baha M Sibai
Treatment and chemoprevention of NSAID-associated gastrointestinal complications
Edward J Frech, Mae F Go
Angioid streaks, clinical course, complications, and current therapeutic management
Ilias Georgalas, Dimitris Papaconstantinou, Chrysanthi Koutsandrea, George Kalantzis, Dimitris Karagiannis, et al
Topical retapamulin in the management of infected traumatic skin lesions
Ribhi Shawar, Nicole Scangarella-Oman, MaryBeth Dalessandro, John Breton, Monique Twynholm, et al
Voiding cystourethrogram in the diagnosis of vesicoureteric reflux in children with antenatally diagnosed hydronephrosis
R B Nerli, S S Amarkhed, I R Ravish
Regular use of traditional analgesics predicts major coronary events: A cohort study
Mikko Haara, Markku Heliövaara, Jari PA Arokoski, Paul Knekt, Pirjo Manninen, et al
Life-threatening hemorrhage following subcutaneous heparin therapy
Jana Hudcova, Daniel Talmor
Management of postoperative nausea and vomiting: focus on palonosetron
Neil A Muchatuta, Michael J Paech
Severe hypotony and filtering bleb leak after intravitreal injection of ranibizumab
Ilias Georgalas, Dimitris Papaconstantinou, Ioannis Tservakis, Chrysanthi Koutsandrea, Ioannis Ladas
Effectiveness and side effects of anti-CD20 therapy for autoantibody-mediated blistering skin diseases: A comprehensive survey of 71 consecutive patients from the Initial use to 2007
Jennifer D Peterson, Lawrence S Chan
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