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Drug Design, Development and Therapy
ISSN: 1177-8881
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Journal Articles:
- Beyond Brain Boundaries: Overcoming the Blood-Brain Barrier to Reach the Central Nervous System (1)
- Using Innovative Drug Delivery Systems to Improve the Efficacy and Applicability of Poorly Water-soluble Drugs (1)
- Advances in design and development of ophthalmic drugs (5)
- A cross-sectional survey on heart failure from China: disease burden and management (3)
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Using Innovative Drug Delivery Systems to Improve the Efficacy and Applicability of Poorly Water-soluble Drugs
Failure of the conventional delivery of poorly water-soluble drugs could be attributed to their low solubility and hence their limited bioavailability that hinder their pharmacological applications. The improvement of drug solubility is of a critical concern in boosting the dissolution rate and bioavailability. Recently, different techniques have been used to increase the solubility and bioavailability of poorly water-soluble drugs. Using novel drug delivery systems and nano-based drug delivery systems can improve their solubility. Moreover, many of these systems act as drug reservoirs that also improve the drug permeability and stability. Accordingly, these delivery systems are important in improving the efficacy and applicability of poorly water-soluble drugs.
A Window for Enhanced Oral Delivery of Therapeutics via Lipid Nanoparticles
Amekyeh H, Sabra R, Billa N
Drug Design, Development and Therapy 2024, 18:613-630
Published Date: 29 February 2024